TCS 2510
Based on 1 Customer Validation
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
The product specifications provided below refer solely to the active content of TCS 2510.
For research use only. We do not sell to patients.
- Purity : 98.30%
- CAS No.: 346673-06-1
- Formula: C21H29N5O2
- Molecular Weight:383.49
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
The product specifications provided below refer solely to the active content of TCS 2510.
IC50 & Target
[1]|
EP4 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
2.5 nM
Compound: 19a
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EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
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[PMID: 12643927] |
| HEK293 | IC50 |
1.4 nM
Compound: 19a
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Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
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[PMID: 12643927] |
In Vitro
TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:0.1~10 mg/kg
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Administration:P.o.
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Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
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Animal Model:Mice[1]
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Dosage:10 mg/kg
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Administration:P.o.
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Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
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Animal Model:Mice[1]
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Dosage:1~10 mg/kg
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Administration:P.o.
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Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
Chemical Information
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CAS No. 346673-06-1
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Appearance Liquid
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Molecular Weight 383.49
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Formula C21H29N5O2
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Color Colorless to light yellow
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SMILES
O=C1N(CCCCCCC2=NNN=N2)[C@@H](/C=C/[C@@H](O)CC3=CC=CC=C3)CC1
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Synonyms
CAY10598
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (289 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TCS 2510 Related Classifications
HY-108557 Related Classifications
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