2. Apoptosis NF-κB
  3. Bcl-2 Family Keap1-Nrf2 Apoptosis
  4. Dehydrobruceine B

Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2.

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Dehydrobruceine B

Dehydrobruceine B 構造式

CAS 番号 : 53730-90-8

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Dehydrobruceine B 関連抗体

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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製品説明

Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].

IC50 & Target[1]

Bax

 

Bcl-xL

 

Bcl-2

 

体外実験

Dehydrobruceine B (1 μM; 48 h) and Cisplatin (3-18 μM; 48 h) combination synergizes the cytotoxic and apoptotic effects in A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) induces excessive generation of intracellular ROS in Cisplatin (3 μM, 6 μM; 24 h)-treated A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) increases depolarization of mitochondrial membrane potential (MMP) and translocation of cytochrome c in Cisplatin (3 μM, 6 μM; 24 h)-treated A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) enhances the change of anti-apoptotic and pro-apoptotic protein levels in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydrobruceine B 関連抗体

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without Cisplatin
Incubation Time: 48 hours
Result: Upregulated the protein level of Bax, while downregulated the levels of Bcl-2 and Bcl-xL.
Enhanced caspase activation and PARP cleavage.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without Cisplatin
Incubation Time: 48 hours
Result: Inhibited cell viability with 9 μM and 18 μM Cisplatin, respectively.
Induced cell apoptosis with 3 μM and 6 μM Cisplatin, respectively.

Immunofluorescence[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without 3 μM and 6 μM Cisplatin, respectively
Incubation Time: 24 hours
Result: Resulted apoptosis-inducing factor (AIF) translocated from cytosol into nucleus dramatically in the co-treatment condition.
分子量

478.45

分子式

C23H26O11
CAS 番号
SMILES

COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5(C(C[C@@]4([H])OC([C@@H]3OC(C)=O)=O)=C(C(C(O)=C5)=O)C)C)=O
Structure Classification
Initial Source

B. antidysenterica and B. guineensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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Dehydrobruceine B Related Classifications

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Keywords:

Dehydrobruceine B53730-90-8Bcl-2 FamilyKeap1-Nrf2ApoptosisInhibitorinhibitorinhibit

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Dehydrobruceine B
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HY-N10313
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