2. Dimercaprol

Dimercaprol  (Synonyms: 2,3-Dimercapto-1-propanol; Dithioglycerol)

Cat. No.: HY-B1285 Purity: 98.02%
COA Handling Instructions

Molarity Calculator

Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning.

For research use only. We do not sell to patients.

Dimercaprol Chemical Structure

Dimercaprol Chemical Structure

CAS No. : 59-52-9

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
Liquid
100 mg USD 55 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Dimercaprol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning[1].

IC50 & Target

HIV[1]
In Vitro

Dimercaprol (10-100 μM; 4 h) could significantly protect PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimercaprol Related Antibodies

Cell Viability Assay[2]

Cell Line: PC-12 cells
Concentration: 10, 25, 50 and 100 μM
Incubation Time: 4 h
Result: Significantly protected PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner.
In Vivo

Dimercaprol (2,3-Dimercapto-1-propanol; 12.5-75 mg/kg; subcutaneous injection; once) increases the death percentage and decreases the mercury contents in liver and kidney[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (13 days old) injected with HgCl2[3]
Dosage: 12.5 mg/kg, 25 mg/kg, 50 mg/kg or 75 mg/kg
Administration: Subcutaneous injection; once
Result: Decreased the mercury contents in liver and kidney.
Molecular Weight

124.23

Formula

C3H8OS2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OCC(S)CS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 41.67 mg/mL (335.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0496 mL 40.2479 mL 80.4958 mL
5 mM 1.6099 mL 8.0496 mL 16.0992 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (804.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.22%

COA (243 KB) HNMR (115 KB) GC (186 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.0496 mL 40.2479 mL 80.4959 mL 201.2396 mL
5 mM 1.6099 mL 8.0496 mL 16.0992 mL 40.2479 mL
10 mM 0.8050 mL 4.0248 mL 8.0496 mL 20.1240 mL
15 mM 0.5366 mL 2.6832 mL 5.3664 mL 13.4160 mL
20 mM 0.4025 mL 2.0124 mL 4.0248 mL 10.0620 mL
25 mM 0.3220 mL 1.6099 mL 3.2198 mL 8.0496 mL
30 mM 0.2683 mL 1.3416 mL 2.6832 mL 6.7080 mL
40 mM 0.2012 mL 1.0062 mL 2.0124 mL 5.0310 mL
50 mM 0.1610 mL 0.8050 mL 1.6099 mL 4.0248 mL
60 mM 0.1342 mL 0.6708 mL 1.3416 mL 3.3540 mL
80 mM 0.1006 mL 0.5031 mL 1.0062 mL 2.5155 mL
100 mM 0.0805 mL 0.4025 mL 0.8050 mL 2.0124 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimercaprol59-52-92,3-Dimercapto-1-propanol DithioglycerolInhibitorinhibitorinhibit

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