6-Phosphogluconic acid
6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite.
For research use only. We do not sell to patients.
- CAS No.: 921-62-0
- Formula: C6H13O10P
- Molecular Weight:276.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
6-Phosphogluconic acid (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 921-62-0
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Molecular Weight 276.14
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Formula C6H13O10P
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SMILES
OC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [Content Brief]
[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Phosphogluconic acid Related Classifications
HY-113514 Related Classifications
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