AP24163
AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC50 values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML).
For research use only. We do not sell to patients.
- CAS No.: 926922-16-9
- Formula: C29H25F3N8O
- Molecular Weight:558.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
24 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
42 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
422 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
422 nM
Compound: la
|
Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay
|
[PMID: 20513156] |
| BaF3 | IC50 |
44 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
63 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
64 nM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
6455 μM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay
|
[PMID: 19572547] |
| BaF3 | IC50 |
7.3 nM
Compound: la
|
Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay
|
[PMID: 20513156] |
| BaF3 | IC50 |
7.3 μM
Compound: 14a, AP24163
|
Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay
Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay
|
[PMID: 19572547] |
| K562 | IC50 |
4.3 μM
Compound: 14a, AP24163
|
Antiproliferative activity against human K562 cells after 3 days by MTS assay
Antiproliferative activity against human K562 cells after 3 days by MTS assay
|
[PMID: 19572547] |
Chemical Information
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CAS No. 926922-16-9
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Molecular Weight 558.56
-
Formula C29H25F3N8O
-
SMILES
O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)