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Cat. No.: HY-182398

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BAY-693

BAY-693 is a highly potent and highly selective ERK5 inhibitor with an IC₅₀ of 6.40 μM. BAY-693 reduces the transcriptional activity of MEF2. BAY-693 is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2306302-48-5
Formula: C₂₆H₃₀F₃N₇O₂
Molecular Weight:529.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BAY-693 Chemical Structure

CAS No.: 2306302-48-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target^[1]

ERK5

6.4 μM (IC₅₀)

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SN12C	IC₅₀	11 μM Compound: BAY-693; 42	Inhibition of ERK5 in human SN12C cells transduced with MEF2-responsive transcription element assessed as reduction in MEF2 transcription by measuring luciferase signal after 16 hrs by luciferase reporter gene assay Inhibition of ERK5 in human SN12C cells transduced with MEF2-responsive transcription element assessed as reduction in MEF2 transcription by measuring luciferase signal after 16 hrs by luciferase reporter gene assay	[PMID: 30563338]

In Vitro

BAY-693 (Compound 42) (16 h) inhibits ERK5-mediated MEF2 transcriptional activity in EGF-stimulated SN12C-MEF2-luc kidney cancer cells with an IC₅₀ of 11.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2306302-48-5
Molecular Weight 529.56
Formula C₂₆H₃₀F₃N₇O₂
SMILES

O=C(N1CCC(CC1)C2=NC(C)=NC3=CC(N4CCN(CC4)C)=CN=C32)C5=CC=C(C=C5N)OC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62(2):928-940.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BAY-693

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BAY-693 Related Classifications

HY-182398 Related Classifications