Clomazone
Based on 1 Customer Validation
Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 81777-89-1
- Formula: C12H14ClNO2
- Molecular Weight:239.70
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Human Metabolite Library
HY-L123
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Pesticide Compound Library
HY-L183
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Environmental Pollutant Compound Library
HY-L247
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Metabolism/Protease Compound Library
HY-L012
Biological Activity
Clomazone (3.1-100 mg a.i./L) inhibits zebrafish embryonic development, and different formulation types significantly affected toxicity manifestations[1].
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Clomazone (50-200 μM) disrupts energy metabolism by inhibiting the mitochondrial electron transport chain and ATP synthase in rat liver mitochondria[2].
Clomazone (0-10 mg/L) exhibits significant hematotoxicity to red-eared slider turtle juveniles by inducing erythrocyte nuclear abnormalities and serum metabolic disorders[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 81777-89-1
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Appearance Solid
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Molecular Weight 239.70
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Formula C12H14ClNO2
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Color White to off-white
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SMILES
O=C1N(CC2=CC=CC=C2Cl)OCC1(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (417.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Stevanovic M, et al. Toxicity of clomazone and its formulations to zebrafish embryos (Danio rerio). Aquat Toxicol. 2017 Jul;188:54-63. [Content Brief]
[2]. Dos Santos Silva HP, et al. Ametryn and Clomazone Disrupt Mitochondrial Bioenergetics in Rat Liver: Evidence for Inhibition of Complexes I and II and ATP Synthase. Toxics. 2025 Sep 16;13(9):784. [Content Brief]
[3]. Tang HB, et al. Herbicide clomazone induced hematotoxicity and hepatic compensatory responses in the invasive turtle, Trachemys scripta elegans. Aquat Toxicol. 2025 Sep;286:107470. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.1719 mL | 20.8594 mL | 41.7188 mL | 104.2970 mL |
| 5 mM | 0.8344 mL | 4.1719 mL | 8.3438 mL | 20.8594 mL | |
| 10 mM | 0.4172 mL | 2.0859 mL | 4.1719 mL | 10.4297 mL | |
| 15 mM | 0.2781 mL | 1.3906 mL | 2.7813 mL | 6.9531 mL | |
| 20 mM | 0.2086 mL | 1.0430 mL | 2.0859 mL | 5.2149 mL | |
| 25 mM | 0.1669 mL | 0.8344 mL | 1.6688 mL | 4.1719 mL | |
| 30 mM | 0.1391 mL | 0.6953 mL | 1.3906 mL | 3.4766 mL | |
| 40 mM | 0.1043 mL | 0.5215 mL | 1.0430 mL | 2.6074 mL | |
| 50 mM | 0.0834 mL | 0.4172 mL | 0.8344 mL | 2.0859 mL | |
| 60 mM | 0.0695 mL | 0.3477 mL | 0.6953 mL | 1.7383 mL | |
| 80 mM | 0.0521 mL | 0.2607 mL | 0.5215 mL | 1.3037 mL | |
| 100 mM | 0.0417 mL | 0.2086 mL | 0.4172 mL | 1.0430 mL |
Clomazone Related Classifications
HY-W040194 Related Classifications
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