HOXC4 - homeobox C4 Gene

Also Known as HOX3; cp19; HOX3E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3221

About HOXC4

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,016,888-54,056,030 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in kidney (RPKM 4.9), ovary (RPKM 2.4) and 16 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]

HOXC4 Products (2)

mRNA Protein Name
NM_014620.6 NP_055435.2 homeobox protein Hox-C4
NM_153633.3 NP_705897.1 homeobox protein Hox-C4

HOXC4 Protein Structure

Homeobox

Homeobox: Homeobox domain (157 - 213)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-C4

  • homeo box 3E

HOXC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXC4 P09017 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
HOXC4 P09017 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
HOXC4 P09017 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
HOXC4 P09017 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
HOXC4 P09017 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
HOXC4 P09017 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
HOXC4 P09017 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
HOXC4 P09017 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
HOXC4 P09017 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
HOXC4 P09017 GDAP1 Homo sapiens Q8TB36
Validated Y2H
32814053
Intra
HOXC4 P09017 GDAP1 Homo sapiens Q8TB36
Y2H Array
32814053
Intra
HOXC4 P09017 GDAP1 Homo sapiens Q8TB36
Y2H Pooling
32814053
Intra
HOXC4 P09017 LMO3 Homo sapiens Q8TAP4-4
Y2H Array
32814053
Intra
HOXC4 P09017 LMO3 Homo sapiens Q8TAP4-4
Y2H Pooling
32814053
Intra
HOXC4 P09017 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32814053
Intra
HOXC4 P09017 TSC1 Homo sapiens Q86WV8
Y2H Array
32814053
Intra
HOXC4 P09017 TSC1 Homo sapiens Q86WV8
Validated Y2H
32814053
Intra
HOXC4 P09017 TSC1 Homo sapiens Q86WV8
Y2H Pooling
32814053
Intra
HOXC4 P09017 CSNK2A1 Homo sapiens P68400
Validated Y2H
32296183
Intra
HOXC4 P09017 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
23455924
Intra
HOXC4 P09017 SUV39H1 Homo sapiens O43463
Y2H
23455924
Intra
HOXC4 P09017 PPIB Homo sapiens P23284
Validated Y2H
32814053
Intra
HOXC4 P09017 PPIB Homo sapiens P23284
Y2H Pooling
32814053
Intra
HOXC4 P09017 PPIB Homo sapiens P23284
Y2H Array
32814053
Intra
HOXC4 P09017 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
HOXC4 P09017 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
HOXC4 P09017 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
HOXC4 P09017 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
HOXC4 P09017 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra
HOXC4 P09017 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra
HOXC4 P09017 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra
HOXC4 P09017 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
HOXC4 P09017 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
HOXC4 P09017 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
HOXC4 P09017 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
HOXC4 P09017 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
HOXC4 P09017 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
HOXC4 P09017 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
HOXC4 P09017 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
HOXC4 P09017 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
HOXC4 P09017 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
HOXC4 P09017 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
HOXC4 P09017 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
HOXC4 P09017 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
HOXC4 P09017 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
HOXC4 P09017 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
HOXC4 P09017 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra
HOXC4 P09017 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra
HOXC4 P09017 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra
HOXC4 P09017 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
HOXC4 P09017 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
HOXC4 P09017 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
HOXC4 P09017 RPRD1B Homo sapiens Q9NQG5
Validated Y2H
32296183
Intra
HOXC4 P09017 HLA-A Homo sapiens Q5SUL5
Validated Y2H
32814053
Intra
HOXC4 P09017 HLA-A Homo sapiens Q5SUL5
Y2H Pooling
32814053
Intra
HOXC4 P09017 HLA-A Homo sapiens Q5SUL5
Y2H Array
32814053
Intra
HOXC4 P09017 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
HOXC4 P09017 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
HOXC4 P09017 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
HOXC4 P09017 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
HOXC4 P09017 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
HOXC4 P09017 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
HOXC4 P09017 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra
HOXC4 P09017 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra
HOXC4 P09017 SNCA Homo sapiens P37840
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 11

  • Autosomal Recessive Congenital Ichthyosis 11

  • Ichthyosis With Hypotrichosis, Autosomal Recessive

  • Arih

  • Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis

  • Autosomal Recessive Ichthyosis With Hypotrichosis

  • ARCI11

  • Ifah

  • Hypotrichosis-Congenital Ichthyosis Syndrome

  • Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome

  • Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome

  • Ichthyosis-Hypotrichosis Syndrome

  • Ifah Syndrome

  • Ihs
Immunodeficiency With Hyper-Igm, Type 2

  • HIGM2

  • Hyper-Igm Syndrome Type 2

  • Hyper-Igm Syndrome 2

  • Immunodeficiency With Hyper-Igm Type 2

  • Activation-Induced Cytidine Deaminase Deficiency

  • Aid Deficiency

  • Immunodeficiency With Hyper Igm Type 2

  • Hyper Igm Syndrome 2

  • Immunodeficiency With Hyper-Igm 2

  • Hyper-Igm Immunodeficiency Type 2

  • Immunodeficiency, With Hyper Igm, Type 2

  • Hyper-Igm Immunodeficiency Syndrome, Type 2
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06317 HOXC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20422 Hoxc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26931 Hoxc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HOXC4 MGD MGI:96195
Bos taurus HOXC4 VGNC VGNC:29925
Felis catus HOXC4 VGNC VGNC:84031
Canis familiaris HOXC4 VGNC VGNC:41759
Rattus norvegicus HOXC4 RGD RGD:1586210
Others HOXC4 NCBI