MCAM - melanoma cell adhesion molecule Gene

Also Known as CD146; MUC18; HEMCAM; METCAM; MelCAM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4162

About MCAM

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,308,529-119,317,130 (from NCBI)

This gene has 17 transcripts (splice variants), 279 orthologues and 3 paralogues. Broad expression in fat (RPKM 237.1), placenta (RPKM 102.0) and 17 other tissues.

Summary

Involved in glomerular filtration and vascular wound healing. Acts upstream of or within angiogenesis. Located in external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided by Alliance of Genome Resources, Apr 2022]

MCAM Products (1)

mRNA Protein Name
NM_006500.3 NP_006491.2 cell surface glycoprotein MUC18 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36739428 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
23878390 GOA
involved in glomerular filtration IEP
IEP: Inferred from expression pattern
20354148 GOA
involved in vascular wound healing IEP
IEP: Inferred from expression pattern
20354148 GOA
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
20354148 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCAM Protein Structure

V-set

V-set: Immunoglobulin V-set domain (29 - 121)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (139 - 234)

Ig_2

Ig_2: Immunoglobulin domain (252 - 324)

ig

ig: Immunoglobulin domain (358 - 409)

Ig_3

Ig_3: Immunoglobulin domain (444 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

cell surface glycoprotein MUC18

  • Gicerin

MCAM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MCAM P43121 FUT2 Homo sapiens Q10981
Anti Bait CoIP
36739428
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MCAM Proteins

Cat. No. Product Name Accession Purity
HY-P75611 CD146/MCAM Protein, Human (HEK293, Fc) P43121-1/NP_006491.2 (V24-G559) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75612 CD146/MCAM Protein, Human (HEK293, His) P43121-1 (V24-G559) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P75613 CD146/MCAM Protein, Human (Biotinylated, HEK293, His) P43121-1/NP_006491.2 (V24-G559) ≥ 95%, as determined by reducing SDS-PAGE.

MCAM Antibodies

Cat. No. Product Name Application Reactivity
HY-P80595 CD146 Antibody (YA544) WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P80595A CD146 Antibody (YA544)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P85790 CD146 Antibody (YA5482) IHC-P, WB, ICC/IF, ELISA Human
HY-P86410 CD146 Antibody (YA6102) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Dental Pulp Disease

  • Dental Pulp Diseases

  • Dental Pulp Disorder

  • Disorder Of Pulp Of Tooth

  • Pulp Disorder
Tibial Nerve Palsy
Dental Pulp Necrosis

  • Pulp Necrosis

  • Necrotic Pulp

  • Necrosis Of The Pulp

  • Dead Pulp

  • Devitalised Pulp

  • Putrescent Pulpitis

  • Devitalized Tooth

  • Dental Pulp Gangrene

  • Pulp Gangrene

  • Nonvital Tooth

  • Pulpless Tooth

  • Putrescent Pulp
Epithelioid Trophoblastic Tumor

  • Trophoblastic Tumor, Epithelioid
Placental Site Trophoblastic Tumor

  • Trophoblastic Tumor Placental Site

  • Trophoblastic Tumor, Placental Site

  • Placental Site Trophoblastic Tumour

  • Placental-Site Gestational Trophoblastic Neoplasm

  • Placenta Neoplasm

  • Psst

  • Deciduoma

  • Placental Cancer

  • Primary Malignant Neoplasm Of Placenta
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Adhesions Of Uterus

  • Intrauterine Adhesions

  • Intrauterine Synechiae

  • Band Of Uterus

  • Asherman Syndrome

  • Internal Adhesion Of Uterus

  • Internal Band Of Uterus
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Osteogenesis Imperfecta, Type Iii

  • Osteogenesis Imperfecta Type Iii

  • OI3

  • Oi, Type Iii

  • Osteogenesis Imperfecta Type 3

  • Oi Type Iii

  • Oi Type 3

  • Progressive Deforming Osteogenesis Imperfecta

  • Severe Osteogenesis Imperfecta

  • Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

  • Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

  • Progressively Deforming Oi

  • Osteogenesis Imperfecta 3

  • Oi-Iii

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Gallbladder Adenocarcinoma

  • Adenocarcinoma Of The Gallbladder

  • Carcinoma Of The Gallbladder
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Methylmalonic Aciduria, Cbla Type

  • Methylmalonic Acidemia Cbla Type

  • Methylmalonic Aciduria Cbla Type

  • Methylmalonic Acidemia, Cbla Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cbla Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Cbla Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive Due To A Defect In Synthesis Of Adenosylcobalamin Cb1a Type

  • Vitamin B12-Responsive Methylmalonic Acidemia Type Cbla

  • Vitamin B12-Responsive Methylmalonic Aciduria Type Cbla

  • Methylmalonic Aciduria Type Cbla

  • MMAA

  • Methylmalonic Aciduria Type A

  • Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl A

  • Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl A

  • Aciduria, Methylmalonic, Cbla Type

  • Methylmalonic Aciduria Cbla Type
Brittle Bone Disorder

  • Osteogenesis Imperfecta

  • Brittle Bone Disease

  • Fragilitas Ossium

  • Osteopsathyrosis

  • Lobstein Disease

  • Oi

  • Vrolik Disease

  • Lobstein'S Disease

  • Lobstein'S Syndrome

  • Vrolik'S Disease

  • Porak And Durante Disease

  • Glass Bone Disease

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal

  • Osteogenesis Imperfecta, Recessive Perinatal Lethal

  • Brittle Bone Syndrome

  • Oi - [Osteogenesis Imperfecta]

  • Ossium Fragility

  • Osteitis Fragilitans

  • Bony Fragility

  • Blue Sclera With Fragility Of Bone And Deafness

  • White Blue Sclera - Fragility Of Bone - Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11288A ANT308 TFA 99.57% Unkown
HY-RS08215 MCAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135698 Methocinnamox Antagonist / Unkown
HY-P11288 ANT308 / Unkown
HY-RS17964 Mcam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24435 Mcam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991609 ABX-MA1 Inhibitor / Unkown
HY-P992430 OI-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MCAM MGD MGI:1933966
Rattus norvegicus MCAM RGD RGD:620463
Macaca mulatta MCAM VGNC VGNC:107457
Others MCAM NCBI