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RNF40 - ring finger protein 40 Gene

Also Known as BRE1B; RBP95; STARING

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9810

About RNF40

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,761,612-30,776,307 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 21.6), bone marrow (RPKM 14.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein Ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

RNF40 Products (4)

mRNA	Protein	Name
NM_001207033.1	NP_001193962.1	E3 ubiquitin-protein ligase BRE1B isoform 2
NM_001207034.1	NP_001193963.1	E3 ubiquitin-protein ligase BRE1B isoform 3
NM_001286572.3	NP_001273501.1	E3 ubiquitin-protein ligase BRE1B isoform 1
NM_014771.4	NP_055586.1	E3 ubiquitin-protein ligase BRE1B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	19575011	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10944455	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10944455	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16307923	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16307923	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16307923	GOA
NOT involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19575011	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HULC complex	IDA IDA: Inferred from direct assay	19410543	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10944455	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16307923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF40 Protein Structure

zf-C3HC4

0
200
400
600
800
1001 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase BRE1B	95 kDa retinoblastoma protein binding protein

RNF40 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF40	O75150	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	RNF40	O75150	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	RNF40	O75150	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	RNF40	O75150	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	RNF40	O75150	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	RNF40	O75150	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
Intra	RNF40	O75150	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	RNF40	O75150	DUSP29	Homo sapiens	Q68J44	Validated Y2H	32296183
Intra	RNF40	O75150	SFR1	Homo sapiens	Q86XK3	Y2H Prey Pooling	25416956
Intra	RNF40	O75150	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	RNF40	O75150	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	RNF40	O75150	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	RNF40	O75150	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	RNF40	O75150	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	RNF40	O75150	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
Intra	RNF40	O75150	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	35271311
Intra	RNF40	O75150	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	19410543
Intra	RNF40	O75150	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	33961781
Intra	RNF40	O75150	NCBP1	Homo sapiens	Q09161	Anti Tag CoIP	35271311
Intra	RNF40	O75150	NCBP1	Homo sapiens	Q09161	Validated Y2H	32296183
Intra	RNF40	O75150	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	RNF40	O75150	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	RNF40	O75150	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	RNF40	O75150	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	RNF40	O75150	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	RNF40	O75150	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	RNF40	O75150	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	RNF40	O75150	ZCCHC12	Homo sapiens	Q6PEW1	Validated Y2H	32296183
Intra	RNF40	O75150	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	32296183
Intra	RNF40	O75150	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RNF40 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82420	RNF40 Antibody (YA2165)	WB, IHC-P, IP	Mouse, Rat, Human

Related Diseases

Diseases	Alias
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W854844A	(E)-JP-2-196 TFA	Ligand	97.89%	Unkown
HY-RS12091	RNF40 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21037	Rnf40 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27554	Rnf40 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF40	VGNC	VGNC:64703
Bos taurus	RNF40	VGNC	VGNC:34066
Macaca mulatta	RNF40	VGNC	VGNC:76745
Canis familiaris	RNF40	VGNC	VGNC:45669
Mus musculus	RNF40	MGD	MGI:2142048
Rattus norvegicus	RNF40	RGD	RGD:628638
Others	RNF40	NCBI