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Cat. No.: HY-N21952

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Heliotridine

Name: Heliotridine
Brand: MedChemExpress
SKU: HY-N21952
Availability: PreOrder

(Synonyms: (+)-Heliotridine)

Heliotridine ((+)-Heliotridine) is a monoesters-type necine base of pyrrolizidine alkaloid with genotoxic and antibacterial properties. Heliotridine can be isolated from the aerial parts of Heliotropium ellipticum, Heliotropium circinatum and other Heliotropium species (Boraginaceae). Heliotridine shows high tolerance in normal human hepatocytes (EC₅₀> 400 μM). Mediated by the organic cation transporter OCT1, Heliotridine exhibits in vitro growth inhibition and weak antibacterial activity against Drechslera tetramera. Heliotridine can be used in infection-related studies of specific pathogenic bacteria.

For research use only. We do not sell to patients.

CAS No.: 520-63-8
Formula: C₈H₁₃NO₂
Molecular Weight:155.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Heliotridine Chemical Structure

CAS No.: 520-63-8

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Heliotridine (2 mg; 0.1 g/mL) exhibits in vitro antimicrobial activity against Drechslera tetramera with a 7 mm zone of inhibition, and shows no measurable activity against all other tested bacteria and fungi^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 520-63-8
Molecular Weight 155.19
Formula C₈H₁₃NO₂
SMILES

OCC1=CCN2[C@@]1([H])[C@@H](O)CC2
Synonyms

(+)-Heliotridine
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. JAIN S C, et al. Antimicrobial activity of pyrrolizidine alkaloids from Heliotropium ellipticum[J]. Chemical and pharmaceutical bulletin, 1987, 35(8): 3487-3489.

[2]. Al-Suhail N, et al. Isolation of Pyrrolizidine Alkaloids from a Newly Recorded Heliotropium Species in Southern Basrah and Evaluation of its Anticancer Potential[J]. Eurasian Journal of Oncology, 2025, 13(3).

[3]. Haas M. Investigation of the hepatotoxic potency of selected genotoxic pyrrolizidine alkaloids and the significance of the DNA damage response[D]. Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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