HOI-07
HOI-07 is a selective Aurora B kinase inhibitor. HOI-07 blocks phosphorylation of histone H3 on Ser10 in lung cancer cells. HOI-07 induces cell-cycle arrest, and apoptosis. HOI-07 has antitumor activity, and suppresses the tumor growth of A549, 143B and KHOS xenografts.
For research use only. We do not sell to patients.
- CAS No.: 1451013-67-4
- Formula: C19H13NO4
- Molecular Weight:319.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Aurora Kinase Isoforms
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Biological Activity
Chemical Information
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CAS No. 1451013-67-4
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Molecular Weight 319.31
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Formula C19H13NO4
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SMILES
O=C1NC2=C(/C1=C\C(/C=C/C3=CC=C4OCOC4=C3)=O)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xie H, et al. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res. 2013 Jan 15;73(2):716-24. [Content Brief]
[2]. Zhao Z, et al. Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma. Mol Carcinog. 2019 Jun;58(6):1056-1067. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HOI-07 Related Classifications
HY-125158 Related Classifications
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