MR22
Based on 1 Customer Validation
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 3027761-24-3
- Formula: C18H19F2N5O
- Molecular Weight:359.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
HY-L009
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Anti-Cancer Compound Library
HY-L025
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Chemical Information
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CAS No. 3027761-24-3
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Appearance Solid
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Molecular Weight 359.37
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Formula C18H19F2N5O
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Color White to off-white
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SMILES
CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (278.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7826 mL | 13.9132 mL | 27.8265 mL | 69.5662 mL |
| 5 mM | 0.5565 mL | 2.7826 mL | 5.5653 mL | 13.9132 mL | |
| 10 mM | 0.2783 mL | 1.3913 mL | 2.7826 mL | 6.9566 mL | |
| 15 mM | 0.1855 mL | 0.9275 mL | 1.8551 mL | 4.6377 mL | |
| 20 mM | 0.1391 mL | 0.6957 mL | 1.3913 mL | 3.4783 mL | |
| 25 mM | 0.1113 mL | 0.5565 mL | 1.1131 mL | 2.7826 mL | |
| 30 mM | 0.0928 mL | 0.4638 mL | 0.9275 mL | 2.3189 mL | |
| 40 mM | 0.0696 mL | 0.3478 mL | 0.6957 mL | 1.7392 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5565 mL | 1.3913 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1594 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8696 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2783 mL | 0.6957 mL |
MR22 Related Classifications
HY-149075 Related Classifications
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