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Cat. No.: HY-B1883R

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Propyzamide (Standard)

Name: Propyzamide (Standard)
Brand: MedChemExpress
SKU: HY-B1883R
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Kerb (Standard); RH 315 (Standard))

Propyzamide (Standard) (Kerb (Standard); RH 315 (Standard)) is the analytical standard of Propyzamide (HY-B1883). This product is intended for research and analytical applications. Propyzamide (Kerb) is an orally active inhibitor of β-tubulin and AHR signaling pathways. Propyzamide binds β-tubulin at the intradimer interface, disrupting microtubule assembly, leading to mitotic arrest and multipolar spindle formation. Propyzamide enhances C/EBPβ and NF-κB signaling, promoting colitogenic helper T cell differentiation and interleukin-17/interferon gamma-expressing colonic T cells. Propyzamide can be used in research on colitis, inflammatory bowel disease, and liver cancer.

For research use only. We do not sell to patients.

Purity : 98%
CAS No.: 23950-58-5
Formula: C₁₂H₁₁Cl₂NO
Molecular Weight:256.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Propyzamide (Standard) Chemical Structure

CAS No.: 23950-58-5

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The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 23950-58-5
Molecular Weight 256.13
Formula C₁₂H₁₁Cl₂NO
SMILES

O=C(NC(C)(C)C#C)C1=CC(Cl)=CC(Cl)=C1
Synonyms

Kerb (Standard); RH 315 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Flemming A. ‘Prime and spike’induces mucosal immunity and reduces SARS-CoV-2 transmission: Covid-19. Nature Reviews Immunology. 2022 Dec;22(12):718-.

[2]. Sanmarco LM, et al. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 Nov;611(7937):801-809.

[3]. Kiessig S, et al. Transcriptional insights into liver toxicity from mixture effects of pesticides and natural toxins: A case study of propyzamide and microcystins. Toxicology. 2026 Dec;527:154580.

[4]. Wojtczak A. Differentiation Disorders of Chara vulgaris Spermatids following Treatment with Propyzamide. Cells. 2023 Apr 27;12(9):1268.

[5]. Wojtczak A, et al. Effect of melatonin on propyzamide-induced stress tolerance in Vigna radiata (L.) R. Wilczek seedlings. BMC Plant Biology. 2026 Sep 3.

[6]. Kaprocki K, et al. Comprehensive analysis of microtubule-inhibiting herbicides reveals shared subcellular phenotypes and distinct resistance profiles. Pest management science. 2026 Sep 02.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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