DMG-PEG2000-F3

DMG-PEG2000-F3 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. F3 peptide: Targeting/functional ligand-the F3 peptide is a fragment of human high-mobility group box 2 (HMGB2) that specifically binds to nucleolin, which is highly expressed on the surface of cancer cells, tumor angiogenesis, and vascular endothelial cell membranes, and enters the cell via clathrin-dependent endocytosis.

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