DPPE-PEG2000-NGR

DPPE-PEG2000-NGR is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. NGR peptide: Targeting/functional ligand-the NGR peptide specifically binds to aminopeptidase N (CD13), which is highly expressed on the surface of tumor neovascular endothelial cells, achieving tumor vascular targeting.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.