Proteins Analysis

PE154 is a fluorescent probe that binds to Aβ plaques, as well as a potent fluorescent inhibitor of AChE and BChE, with an IC₅₀ of 280 pM against hAChE and 16 nM against hBChE. PE154 is applicable for histochemical detection of Aβ plaques in mouse and human brain tissues. PE154 can be used in research related to Alzheimer's disease.

10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate, a phenyl ester of acridinium esters, is a fluorescent dye that produces chemiluminescent under neutral conditions. 10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate can be used for the measurement of hydrogen peroxide.

12-(1-Pyrenyl)dodecanoic acid is a fluorescence probe.

(Rac)-tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins.

AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λ_ex/λ_em=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes.

PROTAC Aster-A degrader-1 is a PROTAC degrader targeting the sterol transporter (Aster-A), with a DC₅₀ of 4.8 μM. PROTAC Aster-A degrader-1 binds to the sterol-binding domain of Aster-A, with a FI-K_d value of 83 nM. PROTAC Aster-A degrader-1 induces CRL- and proteasome-dependent degradation of Aster-A and inhibits autophagy in cancer cells. PROTAC Aster-A degrader-1 serves as a fluorescent probe. PROTAC Aster-A degrader-1 is useful for research related to cervical cancer, breast cancer, and lung adenocarcinoma.

SPY555-BG (SNAP-MaP555) is a cell-permeable fluorescent dye for SNAP-tag labeling of HIV-1 Gag, which enables visualization of HIV-1 intercellular transmission via SNAPf. SPY555-BG relies on irreversible covalent binding to the active-site cysteine of the SNAPf tag fused to HIV-1 Gag.

SNAP-505 is a cell-permeable green fluorescent dye (Ex/Em ≈504/532 nm). It binds specifically and covalently to SNAP-tag fusion proteins, and is used for pulse-chase labeling and localization tracking of proteins in living cells. SNAP-505 can be applied to studies related to insulin granule formation, ER-Golgi protein trafficking, and other relevant processes.

BD140 is a fluorescent probe with a binding affinity K_d of 4.1 μM for binding site 2 of human serum albumin (HSA). BD140 emits activated fluorescence upon binding to the specific HSA binding site 2. BD140 can be combined with dansylamide to form a fluorescent dye mixture, which is used for high-throughput mapping of interaction profiles of HSA drug binding sites (Ex/Em = 356/585 nm).

Activated RPE-Cy5 is a pre-activated dual-color tandem dye for simple and efficient labeling of antibodies or other thiol-containing proteins. It can be used in experiments such as flow cytometry (Ex/Em = 565/667 nm).

Activated RPE-Cy7 is a pre-activated dual-color tandem dye for simple and efficient labeling of antibodies or other thiol-containing proteins. It can be used in experiments such as flow cytometry (Ex/Em = 565/782 nm).

Activated RPE-Cy5.5 is a pre-activated dual-color tandem dye for simple and efficient labeling of antibodies or other thiol-containing proteins, suitable for experiments such as flow cytometry (Ex/Em = 565/695 nm).

Activated PE-Texas Red is a pre-activated dual-color tandem dye for simple and efficient labeling of antibodies, streptavidin, or other proteins. It can be used in experiments such as flow cytometry (Ex/Em = 565/600 nm).

APC Streptavidin is a streptavidin labeled with Allophycocyanin (APC) (HY-D1815) at a concentration of 0.5 mg/mL. Allophycocyanin (APC Dye) is a light-harvesting protein containing a strongly coupled dimer. Streptavidin specifically binds to biotin, forming a reversible non-covalent interaction. R-PE Streptavidin is commonly used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), flow cytometry, and other experiments (Ex/Em=652/662 nm).

R-PE Streptavidin is a streptavidin labeled with R-Phycoerythrin (R-PE) at a concentration of 0.5 mg/mL. R-Phycoerythrin is an orange-red fluorescent probe. Streptavidin specifically binds to biotin, forming a reversible non-covalent interaction. R-PE Streptavidin is commonly used in experiments such as immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), and in situ hybridization (Ex/Em=785/813 nm).

Activated APC-AF750 is a pre-activated dual-color tandem dye for simple and efficient labeling of antibodies or other thiol-containing proteins. It can be used in experiments such as flow cytometry (Ex/Em = 565/780 nm).

HPsensor 2 is a fluorescent probe used to detect the surface hydrophobicity of proteins. The detection mechanism of HPsensor 2 relies on its amphipathic properties. The 2-methoxyethylamine substituents at positions 3 and 5 of its BODIPY core enhance water solubility, enabling it to interact with solvent-exposed hydrophobic regions on proteins. When it binds to these hydrophobic surfaces, the free rotation of the meso-aryl substituent is restricted, increasing molecular rigidity and reducing non-radiative deactivation, which results in a significant enhancement of fluorescence. HPsensor 2 exhibits weak but detectable fluorescence in aqueous environments, and its fluorescence is highly sensitive to changes in protein surface hydrophobicity (Ex/Em = 528/579 nm).

Sulfo-Cyanine3 streptavidin is a streptavidin conjugate of sulfonated Cyanine5, used for high-affinity biotin-binding assays (Ex/Em = 550/570 nm).

Sulfo-Cyanine5 streptavidin is a streptavidin conjugate of sulfonated Cyanine5, used for high-affinity biotin-binding assays (Ex/Em = 650/670 nm).

R-Phycoerythrin (R-PE) (ammonium sulfate precipitate) is found in Heterosiphonia japonica. R-Phycoerythrin (ammonium sulfate precipitate) is an orange-red fluorescent probe with α, β, and γ subunits. R-Phycoerythrin (concentrated solution) can be used in photodynamic therapy (PDT) to induce apoptosis in tumor cells. R-Phycoerythrin (ammonium sulfate precipitate) can be used in fluorescence microscopy, flow cytometry, and immunofluorescence analysis (Ex/Em = 496/578 nm).