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Cat. No.: HY-N21899

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Dysiherbaine

Dysiherbaine is an excitatory amino acid. Dysiherbaine is isolated from the marine sponge Lendenfeldia chondrodes. Dysiherbaine activates AMPA and kainate receptors. Dysiherbaine has minor NMDA receptor agonist activity, while it has no effect on L-type voltage-dependent calcium channels. Dysiherbaine induces convulsions and epileptogenic activity in mice. Dysiherbaine is used in epilepsy research.

For research use only. We do not sell to patients.

CAS No.: 185245-55-0
Formula: C₁₂H₂₀N₂O₇
Molecular Weight:304.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dysiherbaine Chemical Structure

CAS No.: 185245-55-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

^[3]^[5]

AMPA Receptor

NMDA Receptor

Kainate Receptor

All iGluR Isoforms :

In Vitro

Dysiherbaine binds AMPA receptors with a K_i of 153 nM and kainate receptors with a K_i of 26 nM in rat synaptic membrane preparations^[1].
Dysiherbaine activates AMPA and KA receptors in cultured rat hippocampal neurons with EC₅₀ values of 9.7 μM and 210 nM, respectively, and also activates mGlu5^[2].
Dysiherbaine binds with high affinity to GluK1 and GluK2, with K_i values of 0.5 nM and 1.3 nM, respectively^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Dysiherbaine (intracerebroventricular injection, intraperitoneal injection) is highly epileptogenic in mice. Intracerebroventricular injection induces sustained convulsive behavior, with an ED₅₀ of 13 pmol/mouse, and the ED₅₀ value for intraperitoneal injection is 0.97 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 185245-55-0
Molecular Weight 304.30
Formula C₁₂H₂₀N₂O₇
SMILES

OC([C@@H](N)C[C@]1(O[C@@]2([H])[C@@](OC[C@H]([C@H]2NC)O)([H])C1)C(O)=O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
Dysidea herbacea
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sasaki M, et al. Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes. Bioorganic & medicinal chemistry letters. 2006 Nov 15;16(22):5784-7.

[2]. Sakai R, et al. Physiological study of an excitatory amino acid dysiherbaine[C]//Proceedings of Annual Meeting of the Physiological Society of Japan Proceedings of Annual Meeting of the Physiological Society of Japan. PHYSIOLOGICAL SOCIETY OF JAPAN, 2004: S13-S13.

[3]. Swanson GT, et al. Ligands for ionotropic glutamate receptors. InMarine Toxins as Research Tools 2009 Jan 1 (pp. 123-157). Berlin, Heidelberg: Springer Berlin Heidelberg.

[4]. Sanders JM, et al. Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors. Molecular pharmacology. 2006 Jun;69(6):1849-60.

[5]. Minei R, et al. [Effects of a new excitotoxic amino acid, dysiherbaine, on cultured Müller cells]. Nippon Ganka Gakkai zasshi. 1999 Aug;103(8):584-90.

[6]. Unno M, et al. Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors. Journal of molecular biology. 2011 Oct 28;413(3):667-83.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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