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Cat. No.: HY-117707

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EBI-907

EBI-907 is an orally active and highly potent B-Raf^V600E inhibitor. EBI-907 demonstrates excellent A375 and Colo-205 cellular antiproliferative activity with IC₅₀ values of 13 nM and 14 nM, respectively. EBI-907 can also cause tumor regression in a B-Raf^V600E-dependent Colo-205 tumor xenograft model of mice. EBI-907 is promising for research of melanoma and B-Raf^V600E associated cancers.

For research use only. We do not sell to patients.

CAS No.: 1581764-31-9
Formula: C₂₃H₂₁ClF₂N₄O₃S
Molecular Weight:506.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

EBI-907 Chemical Structure

CAS No.: 1581764-31-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	13 nM Compound: 13g; EBI-907	Growth inhibition of human A375 cells Growth inhibition of human A375 cells	[PMID: 26739779]
Calu-6	IC₅₀	455 nM Compound: 13g; EBI-907	Growth inhibition of human Calu6 cells carrying a wild-type B-Raf Growth inhibition of human Calu6 cells carrying a wild-type B-Raf	[PMID: 26739779]
COLO 205	IC₅₀	14 nM Compound: 13g; EBI-907	Growth inhibition of human COLO205 cells Growth inhibition of human COLO205 cells	[PMID: 26739779]

Chemical Information

CAS No. 1581764-31-9
Molecular Weight 506.95
Formula C₂₃H₂₁ClF₂N₄O₃S
SMILES

O=S(NC1=CC=C(C(C2=CC3=CNC4=NN=C(C5CC5)C4=C3C=C2OC)=C1Cl)F)(CCCF)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu B, et al. Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-823. [Content Brief]

[2]. Zhang J, et al. EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile. Cancer Biol Ther. 2016;17(2):199-207. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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