2. GPCR/G Protein
  3. GCGR
  4. Ecnoglutide

Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ecnoglutide Chemical Structure

Ecnoglutide Chemical Structure

CAS No. : 2459531-73-6

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1 mg USD 50 In-stock
5 mg USD 125 In-stock
10 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

Ecnoglutide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity[1][2].

In Vitro

Ecnoglutide induces cAMP but not GLP-1 receptor internalization (EC50 = 0.018 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ecnoglutide Related Antibodies
In Vivo

Ecnoglutide (0.015, 0.15 mg/kg, s.c., a single time) reduces blood glucose, promotes insulin induction, and leads to more pronounced body weight reduction compared to Semaglutide (HY-114118) in db/db mice[2].
Ecnoglutide (1 mg/kg, s.c., rats) shows the T1/2 (h), Tmax (h), Cmax (nM), AUClast (h*nM), MRT (h) values of 11.7, 18 .0, 387.3, 16274.8, 25.4 respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

4284.76

Formula

C₁₉₄H₃₀₄N₄₈O₆₁
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

His-Val-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Arg-Glu-Phe-Ile-Lys-(AEEA-AEEA-{γ-Glu}-C18 diacid)-Trp-Leu-Val-Arg-Gly-Arg-Gly
Sequence Shortening

HVEGTFTSDVSSYLEEQAAREFIK-(AEEA-AEEA-{γ-Glu}-C18 diacid)-WLVRGRG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (5.83 mM; Need ultrasonic)

H2O : 20 mg/mL (4.67 mM; ultrasonic and adjust pH to 12 with 1M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2334 mL 1.1669 mL 2.3339 mL
5 mM 0.0467 mL 0.2334 mL 0.4668 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 0.2334 mL 1.1669 mL 2.3339 mL 5.8346 mL
H2O 5 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1669 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ecnoglutide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ecnoglutide2459531-73-6XW003XW 003XW-003GCGRGlucagon ReceptorcAMPT2DMobesityInhibitorinhibitorinhibit

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