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Cat. No.: HY-157078

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Eg5-IN-2

Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC₅₀: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs.

For research use only. We do not sell to patients.

CAS No.: 1629735-05-2
Formula: C₃₁H₃₈F₃N₅O₃
Molecular Weight:585.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Eg5-IN-2 Chemical Structure

CAS No.: 1629735-05-2

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Biological Activity

Description

Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC₅₀: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs^[1].

All ADC Payloads Isoforms :

Chemical Information

CAS No. 1629735-05-2
Molecular Weight 585.66
Formula C₃₁H₃₈F₃N₅O₃
SMILES

CNC(CC([C@H](C1=NC(C2=CC(F)=CC=C2F)=CN1CC3=CC=CC=C3)N(C[C@H]4[C@H](CNC4)F)C([C@@H](O)C)=O)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10(12):1674-1679. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Eg5-IN-2

All ADC Payloads Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Eg5-IN-2 Related Classifications

HY-157078 Related Classifications