EGFR-IN-104
EGFR-IN-104 (Compound A23) is an effective inhibitor of EGFR, with IC50 values of 0.33 μM and 0.133 μM against EGFRL858R/T790M and EGFRDel19/T790M/C797S, respectively. EGFR-IN-104 exhibits anticancer activity both in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 2758904-45-7
- Formula: C23H27N7OS
- Molecular Weight:449.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
Description
IC50 & Target
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EGFRL858R/T790M 0.33 μM (IC50) |
EGFRL858R/T790M/C797S 0.133 μM (IC50) |
Chemical Information
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CAS No. 2758904-45-7
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Molecular Weight 449.57
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Formula C23H27N7OS
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SMILES
OC1=CC=CC=C1C2=NC(CCSC3)=C3C(NCC4=CN=C(N5CCN(C)CC5)N=C4)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)