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Cat. No.: HY-162891

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EGFR-IN-123

EGFR-IN-123 (compound D06) is a potent EGFR inhibitor. EGFR-IN-123 inhibits PC-9G, A549, A431 and HCT116 cells with IC₅₀s of 0.74, 1.36, 1.20 and 2.53 μM, respectively.

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CAS No.: 2543763-00-2
Formule: C₂₄H₂₇F₃N₆O
Masse moléculaire:472.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

EGFR-IN-123 Chemical Structure

CAS No.: 2543763-00-2

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

EGFR-IN-123 (compound D06) is a potent EGFR inhibitor. EGFR-IN-123 inhibits PC-9G, A549, A431 and HCT116 cells with IC₅₀s of 0.74, 1.36, 1.20 and 2.53 μM, respectively^[1].

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Chemical Information

CAS No. 2543763-00-2
Masse moléculaire 472.51
Formule C₂₄H₂₇F₃N₆O
SMILES

COC1=CC=CC(NC2=CC(NC3=CC=C(CN4CCN(C)CC4)C(C(F)(F)F)=C3)=NC=N2)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. FaQing Ye,et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.

[2]. FaQing Ye,et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR-IN-123

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Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EGFR-IN-123 Related Classifications

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