EGFR-IN-158
EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 of 0.22 nM for EGFR(Del19/T790M). EGFR-IN-158 inhibits phosphorylation and downstream signaling by binding to EGFR, thereby inhibiting the proliferation of tumor cell lines and promoting apoptosis.
For research use only. We do not sell to patients.
- Formula: C27H35ClN8O4S
- Molecular Weight:603.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
Chemical Information
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Molecular Weight 603.14
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Formula C27H35ClN8O4S
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SMILES
C=CC(NC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(NCC)=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)