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Cat. No.: HY-179148

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EGFR-IN-184

EGFR-IN-184 (compound 5p) is an EGFR inhibitor (IC₅₀ = 65.6 nM). EGFR-IN-184 has anti proliferative activity against various tumor cells, such as T47D (IC₅₀ = 15 μM), PC3 (IC₅₀ = 55 μM), HCT116 (IC₅₀ = 36 μM) cells. EGFR-IN-184 can significantly induce cell apoptosis and block the cell cycle. EGFR-IN-184 can be used for research on various types of cancer.

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Formule: C₂₀H₁₆ClN₅O₃S
Masse moléculaire:441.89

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

EGFR-IN-184 Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

Chemical Information

Masse moléculaire 441.89
Formule C₂₀H₁₆ClN₅O₃S
SMILES

CC1=CC2=C(N=C(S2)NC(CN3C=C(N=N3)COC(C4=CC=C(C=C4)Cl)=O)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Alsehli M, et al. Click synthesis of some novel benzo[d]thiazole-1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer. RSC Med Chem. 2025 Sep 2. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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EGFR-IN-184

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EGFR-IN-184 Related Classifications

HY-179148 Related Classifications