EGFR-IN-203
EGFR-IN-203 is a EGFR kinase domain inhibitor targeting EGFRT790M/C797S/V948R. EGFR-IN-203 stably binds to the allosteric pocket of EGFR in an inactive conformation. EGFR-IN-203 can be used in research related to cancers such as non-small cell lung cancer.
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- CAS. Nr.: 3105969-17-0
- Formel: C38H32N4O4
- Molecular Weight:608.69
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
EGFR-IN-203 (Compound 3h389) stably binds to the allosteric pocket of the EGFR kinase domain in the EGFRT790M/C797S/V948R mutant via dominant electrostatic interactions, and exhibits an extremely strong absolute binding free energy of -25.6 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3105969-17-0
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Molecular Weight 608.69
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Formel C38H32N4O4
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SMILES
COC(C1=CC2=C(NC=C2C(C3=CNC4=C3C=C(C=C4)C(OC)=O)C5=CC=C(C=C5)C6NCCC7=C6NC8=CC=CC=C87)C=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EGFR-IN-203 Related Classifications
HY-181714 Related Classifications
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