EGFR-IN-21
EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity.
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- No. CAS: 2648206-31-7
- Fòrmula: C36H44BrN10O2P
- Peso molecular:759.68
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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EGFR 0.38 nM (IC50) |
EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2648206-31-7
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Peso molecular 759.68
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Fòrmula C36H44BrN10O2P
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SMILES
O=P(C)(C)C1=C2C=CC=CC2=NC=C1NC3=NC(NC4=CC(C5=CN(C)N=C5)=C(N6CCC(CC6)N7CCN(CC7)C)C=C4OC)=NC=C3Br
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-21 Related Classifications
HY-142678 Related Classifications
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