2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-21

EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity.

For research use only. We do not sell to patients.

EGFR-IN-21 Chemical Structure

EGFR-IN-21 Chemical Structure

CAS No. : 2648206-31-7

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EGFR-IN-21 Related Antibodies

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Description

EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].

IC50 & Target[1]

EGFR

0.38 nM (IC50)

In Vitro

EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-21 Related Antibodies
In Vivo

EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1].
EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

759.68

Formula

C36H44BrN10O2P
CAS No.
SMILES

O=P(C)(C)C1=C2C=CC=CC2=NC=C1NC3=NC(NC4=CC(C5=CN(C)N=C5)=C(N6CCC(CC6)N7CCN(CC7)C)C=C4OC)=NC=C3Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-212648206-31-7EGFREpidermal growth factor receptorErbB-1HER1HEK293TPC9 EGFR-Del19/T790M/C797SInhibitorinhibitorinhibit

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EGFR-IN-21
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