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Cat. No.: HY-142679

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EGFR-IN-22

EGFR-IN-22 is a potent EGFR inhibitor with IC₅₀s of 4.91 nM and 0.54 nM for wild type EGFR and EGFR^{L858R/T790M/C797S}, respectively (CN112538072A, compound 243).

For research use only. We do not sell to patients.

CAS No.: 2634646-14-1
Formula: C₃₈H₄₇BrFN₁₀O₂P
Molecular Weight:805.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR-IN-22 Chemical Structure

CAS No.: 2634646-14-1

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR-IN-22 is a potent EGFR inhibitor with IC₅₀s of 4.91 nM and 0.54 nM for wild type EGFR and EGFR^{L858R/T790M/C797S}, respectively (CN112538072A, compound 243)^[1].

IC₅₀ & Target^[1]

EGFR^{L858R/T790M/C797S}

0.54 nM (IC₅₀)

EGFR (WT)

4.91 nM (IC₅₀)

All EGFR Isoforms :

Chemical Information

CAS No. 2634646-14-1
Molecular Weight 805.72
Formula C₃₈H₄₇BrFN₁₀O₂P
SMILES

O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC6(CCN(C(C)(CF)C)CC6)CC5)C(C7=CN(C)N=C7)=C4)=NC=C3Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. EGFR-IN-22 is a potent EGFR inhibitor with IC50 of 4.91 nM and 0.54 nM for wild type EGFR and EGFR^{L858R/T790M/C797S}, respectively (CN112538072A, compound 243)^[1].

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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EGFR-IN-22

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-IN-22 Related Classifications

HY-142679 Related Classifications