1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR-IN-36

EGFR-IN-36 

Cat. No.: HY-144053
Handling Instructions

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research.

For research use only. We do not sell to patients.

EGFR-IN-36 Chemical Structure

EGFR-IN-36 Chemical Structure

CAS No. : 2711105-54-1

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Description

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].

IC50 & Target[1]

EGFR (WT)

19.09 nM (IC50)

HER2(WT)

120.01 nM (IC50)

HER2 (A775_G776insYVMA)

2.35 nM (IC50)

In Vitro

EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.97

Formula

C26H25ClN6O2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR-IN-36
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HY-144053
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