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Cat. No.: HY-187217

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ERα-IN-2

ERα-IN-2 is a ERα inhibitor. ERα-IN-2 blocks agonist-induced recruitment of nuclear receptor-binding peptides to the ligand-binding domain of ERα and exerts selective antiproliferative effects in breast cancer cells. ERα-IN-2 can be used in breast cancer-related research.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₃ClN₂O₃S
Molecular Weight:372.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ERα-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

ERα

All Estrogen Receptor/ERR Isoforms :

In Vitro

ERα-IN-2 (compound 14b) (treated overnight) inhibits E2-induced recruitment of the SRC1-II peptide to ERα LBD in TR-FRET assays, with an IC₅₀ of 1.58 μM^[1].
ERα-IN-2 (0-50 μM; 48 h) inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells, with IC₅₀ values of 11 μM and 45 μM, respectively; it also exhibits weak antiproliferative activity against non-cancerous HaCaT keratinocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 372.83
Formula C₁₈H₁₃ClN₂O₃S
SMILES

O=C1N(C2=NOC(C3=CC=CC=C3)=C2)[C@@H](C4=CC=CC(O)=C4Cl)SC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Colarusso E, et al. Repositioning of 3-(isoxazol-3-yl)thiazolidin-4-one-based compounds via Inverse Virtual Screening: discovery of new ERα inhibitors with in vitro activity in breast cancer models. European journal of medicinal chemistry. 2026 Jul 08;317:119136. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ERα-IN-2

All Estrogen Receptor/ERR Isoforms