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Cat. No.: HY-124922

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CBLC100

CBLC100 is an anticancer compound that targets FACT, while inhibiting NF-κB and activating p53. CBLC100 induces cytotoxicity through p53-dependent apoptotic and non-apoptotic pathways. CBLC100 is applicable to the research of cancers such as fibrosarcoma.

For research use only. We do not sell to patients.

CAS No.: 1197996-83-0
Formula: C₂₄H₂₆N₂O₂
Molecular Weight:374.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

CBLC100 Chemical Structure

CAS No.: 1197996-83-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All NF-κB Isoforms :

In Vitro

CBLC100 potently activates p53 and inhibits NF-κB in cell-based reporter gene assays, with corresponding EC₅₀ values of 0.03 μM and 0.06 μM^[1].
CBLC100 exerts selective cytotoxicity against human fibrosarcoma HT1080 cells, while showing low toxicity toward normal human Wi38 diploid fibroblasts^[1].
CBLC100 (0.2 μM; 1 h) traps the FACT complex on the chromatin of human fibrosarcoma HT1080 cells, while depleting soluble FACT subunits in the nucleoplasm^[1].
CBLC100 enhances CK2-mediated phosphorylation of the C-terminal region of p53 in human fibrosarcoma HT1080 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1197996-83-0
Molecular Weight 374.48
Formula C₂₄H₂₆N₂O₂
SMILES

O=C1CCC2=C1C=CC3=C2C4=C(C=CC5=C4CCC5=O)N3CCN(CC)CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3(95):95ra74. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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CBLC100

All NF-κB Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CBLC100 Related Classifications

HY-124922 Related Classifications