Menaquinone 9
Based on 1 Customer Validation
Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 523-39-7
- Formula: C56H80O2
- Molecular Weight:785.23
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Lipid Compound Library
HY-L043
-
Antibacterial Compound Library
HY-L049
-
Orally Active Compound Library
HY-L061
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
All Endogenous Metabolite Isoforms
More
Biological Activity
Menaquinone 9 (in the form of oxidized derivatives) binds specifically to the ab dimer of heat-released *E. coli* PK27 nitrate reductase; and undergoes photooxidation in the presence of air to produce more polar degradation products[1].
Menaquinone 9 (in anaerobic form) specifically binds to the heat-transformed nitrate reductase ab dimer of *Escherichia coli* PK27[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (4-week-old male and female)[2]
-
Dosage:0.06 mg/kg diet; 2.1 mg/kg diet; 0.06 mg/kg deuterium-labeled MK9 diet; 2.1 mg/kg deuterium-labeled MK9 diet
-
Administration:p.o.; daily; 12 weeks (non-deuterated MK9); p.o.; daily; 1 week (deuterium-labeled MK9)
-
Result:Increased liver MK4 and MK9 concentrations significantly in mice fed 2.1 mg MK9/kg diet compared to those fed 0.06 mg MK9/kg diet.
Detected MK4 as the only vitamin K form in bone; increased bone MK4 concentrations significantly in mice fed 2.1 mg MK9/kg diet compared to those fed 0.06 mg MK9/kg diet.
Demonstrated 63%-67% of skeletal MK4 was derived from labeled MK9 in mice fed 2.1 mg/kg deuterium-labeled MK9; reached labeled MK4 concentrations of 22 pmol/g in males and 37 pmol/g in females.
Showed no significant differences in femoral tissue strength, maximum bending moment, section modulus, femur length, and total body BMD between diet groups in either sex.
Decreased femoral cross-sectional area and moment of inertia significantly in female mice fed 2.1 mg MK9/kg diet compared to those fed 0.06 mg MK9/kg diet; observed no such differences in male mice.
Chemical Information
-
CAS No. 523-39-7
-
Appearance Solid
-
Molecular Weight 785.23
-
Formula C56H80O2
-
Color White to yellow
-
SMILES
O=C1C(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)C(C2=C1C=CC=C2)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : 2 mg/mL (2.55 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
References
[1]. Brito F, et al. Isolation and identification of menaquinone-9 from purified nitrate reductase of Escherichia coli. Journal of bacteriology. 1995 Jul;177(13):3728-35. [Content Brief]
[2]. Liu M, et al. Dietary menaquinone-9 supplementation does not influence bone tissue quality or bone mineral density during skeletal development in mice. JBMR plus. 2025 Jun;9(6):ziaf059. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.2735 mL | 6.3676 mL | 12.7351 mL | 31.8378 mL |
Menaquinone 9 Related Classifications
HY-131501 Related Classifications
Powered by Bioz