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Cat. No.: HY-161309

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RUPB-61

RUPB-61 is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC₅₀ value of 13 nM. RUPB-61 shows antiparasitic activity.

For research use only. We do not sell to patients.

CAS No.: 3032827-64-5
Formula: C₂₂H₂₄FN₃
Molecular Weight:349.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

RUPB-61 Chemical Structure

CAS No.: 3032827-64-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

RUPB-61 is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC₅₀ value of 13 nM. RUPB-61 shows antiparasitic activity^[1].

IC₅₀ & Target

IC₅₀:13 nM (PfPKG)^[1]

All Parasite Isoforms :

Chemical Information

CAS No. 3032827-64-5
Molecular Weight 349.44
Formula C₂₂H₂₄FN₃
SMILES

FC(C=C1)=CC=C1C(NC([C@@H]2[C@H](C)CN(C)CC2)=C3)=C3C4=CC=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gilleran JA, et al. Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J Med Chem. 2024 Feb 19. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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RUPB-61

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RUPB-61 Related Classifications

HY-161309 Related Classifications