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Referencia número: HY-15873

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FTI 276

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 170006-72-1
Fòrmula: C₂₁H₂₇N₃O₃S₂
Peso molecular:433.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FTI 276 Chemical Structure

No. CAS: 170006-72-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

IC₅₀ & Target

IC50: 0.9 and 0.5 nM for Plasmodium falciparum and human^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	>10000 nM Compound: Hamilton FTI	Inhibition of human adenocarcinoma cell line Caco-2 proliferation Inhibition of human adenocarcinoma cell line Caco-2 proliferation	[PMID: 11784156]
LoVo	IC₅₀	50 nM Compound: Hamilton FTI	Inhibition of human adenocarcinoma cell line LoVo proliferation Inhibition of human adenocarcinoma cell line LoVo proliferation	[PMID: 11784156]
NIH3T3	EC₅₀	1 μM Compound: 1	Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells	[PMID: 10201832]
NIH3T3	IC₅₀	1 μM Compound: 1 (FTI-276)	Inhibition of mammalian H-Ras processing in NIH 3T3 cells Inhibition of mammalian H-Ras processing in NIH 3T3 cells	[PMID: 11277514]
NIH3T3	ED₅₀	>25 μM Compound: FTI-276	Effective dose against murine 3T3 fibroblasts cells Effective dose against murine 3T3 fibroblasts cells	[PMID: 14711313]
NIH3T3	ED₅₀	1 μM Compound: 1	Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells. Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.	[PMID: 9784104]

Chemical Information

No. CAS 170006-72-1
Peso molecular 433.59
Fòrmula C₂₁H₂₇N₃O₃S₂
SMILES

O=C(O)[C@@H](NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chakrabarti D, et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.J Biol Chem. 2002 Nov 1; 277(44):42066-73. Epub 2002 Aug 22. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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