Taniborbactam
Based on 17 publication(s) in Google Scholar
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria.
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- Pureza: 98.45%
- No. CAS: 1613267-49-4
- Fòrmula: C19H28BN3O5
- Peso molecular:389.25
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Taniborbactam
More- Engineering (Beijing). 2024 Jul:38:124-132. [Abstract]
- Int J Antimicrob Agents. 2025 Jun 20:107557. [Abstract]
- Int J Antimicrob Agents. 2024 Jan;63(1):107030. [Abstract]
- Sci Rep. 2025 Sep 29;15(1):33616. [Abstract]
- Int J Infect Dis. 2025 Dec 4:163:108279. [Abstract]
- Antimicrob Agents Chemother. 2025 Dec 29:e0128625. [Abstract]
- Antimicrob Agents Chemother. 2025 Dec 5:e0084225. [Abstract]
- Antimicrob Agents Chemother. 2025 Jun 9:e0029725. [Abstract]
- Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0077524. [Abstract]
- Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]
- Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0033923. [Abstract]
- Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0167621. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- J Antimicrob Chemother. 2023 May 3;78(5):1191-1194. [Abstract]
- mSphere. 2025 Dec 23;10(12):e0041825. [Abstract]
- J Glob Antimicrob Resist. 2025 Jul 7:44:265-271. [Abstract]
- FEMS Microbiol Lett. 2025 Jan 10:372:fnaf044. [Abstract]
Ver todos los productos específicos de isoformas Beta-lactamase
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Actividad biológica
β-lactamase[1]
Taniborbactam (VNRX-5133) has IC50s of 0.5 nM, 2 nM, 0.5 nM, 0.06 nM for KPC-2, OXA-48, VIM-4 of K.pneumoniae strain and VIM-2 of P.aeruginosa strain[2].
Both cefepime/Taniborbactam (10 μg/mL) and meropenem/Taniborbactam combinations are highly active against all six of the NDM-1-producing clinical isolates from K.pneumoniae and E.coli, with MIC ranges of 16-0.25 and 1-0.125 μg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Combination of Cefepime (16 mg/kg) and Taniborbactam (16 mg/kg; s.c.; twice-a-day for 7 days) demonstrates >2 log10 reductions in viable bacterial counts in the kidney of the ascending urinary tract infection model against a CTX-M-15-producing strain of E.coli[2].
Taniborbactam has a T1/2 of 0.16 hours, a CL of 618 mL/h/kg, and a Vss of 143 mL/kg for mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1613267-49-4
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Appearance Solid
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Peso molecular 389.25
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Fòrmula C19H28BN3O5
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Color White to off-white
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SMILES
OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O
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Synonyms
VNRX-5133
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (17)
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Journal Impact Factor
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Most Recent
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Engineering (Beijing)
The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers. [Abstract]2024 Jul:38:124-132. PMID: 40109291 -
Int J Antimicrob Agents
2025 Jun 20:107557. PMID: 40545056 -
Int J Antimicrob Agents
Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediating resistance to avibactam-based β-lactamase inhibitor combinations and cefiderocol. [Abstract]2024 Jan;63(1):107030. PMID: 37931849 -
Sci Rep
Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors. [Abstract]2025 Sep 29;15(1):33616. PMID: 41023121 -
Int J Infect Dis
Susceptibilities of cefiderocol, meropenem-xeruborbactam, cefepime-taniborbactam, aztreonam-avibactam, and sulbactam-durlobactam against imipenem-non-susceptible Gram-negative bacilli in Taiwan. [Abstract]2025 Dec 4:163:108279. PMID: 41349864 -
Antimicrob Agents Chemother
NDM-63: a novel NDM metallo-β-lactamase variant in the L3 loop, from a Klebsiella pneumoniae clinical isolate. [Abstract]2025 Dec 29:e0128625. PMID: 41460102 -
Antimicrob Agents Chemother
Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales. [Abstract]2025 Dec 5:e0084225. PMID: 41347523 -
Antimicrob Agents Chemother
The emerging concern of IMP variants being resistant to the only IMP-type metallo-β-lactamase inhibitor, xeruborbactam. [Abstract]2025 Jun 9:e0029725. PMID: 40488615 -
Antimicrob Agents Chemother
Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases. [Abstract]2024 Nov 6;68(11):e0077524. PMID: 39365068 -
Antimicrob Agents Chemother
2024 Feb 7;68(2):e0133223. PMID: 38174924 -
Antimicrob Agents Chemother
Impact of Acquired Broad Spectrum β-Lactamases on Susceptibility to Novel Combinations Made of β-Lactams (Aztreonam, Cefepime, Meropenem, and Imipenem) and Novel β-Lactamase Inhibitors in Escherichia coli and Pseudomonas aeruginosa. [Abstract]2023 Jul 18;67(7):e0033923. PMID: 37255469 -
Antimicrob Agents Chemother
Assessment of Activity and Resistance Mechanisms to Cefepime in Combination with the Novel β-Lactamase Inhibitors Zidebactam, Taniborbactam, and Enmetazobactam against a Multicenter Collection of Carbapenemase-Producing Enterobacterales. [Abstract]2022 Feb 15;66(2):e0167621. PMID: 34807754 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
J Antimicrob Chemother
In vitro activity of cefepime/zidebactam and cefepime/taniborbactam against aztreonam/avibactam-resistant NDM-like-producing Escherichia coli clinical isolates. [Abstract]2023 May 3;78(5):1191-1194. PMID: 36921067 -
mSphere
APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers. [Abstract]2025 Dec 23;10(12):e0041825. PMID: 41334908 -
J Glob Antimicrob Resist
Genomic characterization of carbapenem-resistant Pseudomonas aeruginosa from ICU admission screening in Hanoi, Vietnam, 2023. [Abstract]2025 Jul 7:44:265-271. PMID: 40633763 -
FEMS Microbiol Lett
The NitroSpeed Taniborbactam NP test as a rapid test for detection of β-lactamase-mediated susceptibility to taniborbactam. [Abstract]2025 Jan 10:372:fnaf044. PMID: 40328681
Solvente y solubilidad
DMSO : 25 mg/mL (64.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556. [Content Brief]
[2]. Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5690 mL | 12.8452 mL | 25.6904 mL | 64.2261 mL |
| 5 mM | 0.5138 mL | 2.5690 mL | 5.1381 mL | 12.8452 mL | |
| 10 mM | 0.2569 mL | 1.2845 mL | 2.5690 mL | 6.4226 mL | |
| 15 mM | 0.1713 mL | 0.8563 mL | 1.7127 mL | 4.2817 mL | |
| 20 mM | 0.1285 mL | 0.6423 mL | 1.2845 mL | 3.2113 mL | |
| 25 mM | 0.1028 mL | 0.5138 mL | 1.0276 mL | 2.5690 mL | |
| 30 mM | 0.0856 mL | 0.4282 mL | 0.8563 mL | 2.1409 mL | |
| 40 mM | 0.0642 mL | 0.3211 mL | 0.6423 mL | 1.6057 mL | |
| 50 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2845 mL | |
| 60 mM | 0.0428 mL | 0.2141 mL | 0.4282 mL | 1.0704 mL |
Taniborbactam Related Classifications
HY-109124 Related Classifications
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