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Referencia número: HY-184280

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Anticancer agent 329

Anticancer agent 329 is a mitochondria-targeted Podophyllotoxin (HY-15552) derivative conjugated with F16 (HY-100395), and also acts as an anticancer agent. Anticancer agent 329 accumulates in mitochondria and induces Apoptosis in a concentration-dependent manner. Anticancer agent 329 can be used in the research of liver cancer, colorectal cancer, non-small cell lung cancer and breast cancer.

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No. CAS: 3128226-38-7
Fòrmula: C₄₅H₄₇BrN₂O₉
Peso molecular:839.77

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 329 Chemical Structure

No. CAS: 3128226-38-7

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

In Vitro

Anticancer agent 329 (Compound 6d) potently inhibits the proliferation of HepG2, HCT116, A549, and MDA-MB-231 cells with IC₅₀ values of 0.66 μM, 1.10 μM, 2.00 μM, and 3.31 μM respectively, and exhibits a selectivity index of 2.29 for HepG2 cells over normal QSG-7701 hepatocytes^[1].
Anticancer agent 329 (1.2-4.8 μM; 24 h) induces apoptosis in HepG2 cells in a concentration-dependent manner, with total apoptosis rates reaching 17.79% at a 4.8 μM 24-hour treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3128226-38-7
Peso molecular 839.77
Fòrmula C₄₅H₄₇BrN₂O₉
SMILES

O=C(OC1)[C@@H]([C@H]1[C@H]2OC(CCCCCCC[N+]3=CC=C(/C=C/C4=CNC5=C4C=CC=C5)C=C3)=O)[C@H](C6=CC(OC)=C(OC)C(OC)=C6)C(C2=C7)=CC8=C7OCO8.[Br-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Xu C, et al. Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer. Bioorganic & medicinal chemistry letters. 2026 Jul;136:130591. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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