CCTA-1523
CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity.
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- No. CAS: 1616271-41-0
- Fòrmula: C16H15Cl2NO3
- Peso molecular:340.20
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
CCTA-1523 (0-1000 µM; 72 h) shows cytotoxicity for H460, H460/MX20, HEK293/pcDNA3.1, HEK/R482, HEK/R482G and HEK/R482T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCR nude mice (H460/MX20 xenografts)[1]
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Dosage:75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
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Administration:P.o.;q3d x 6
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Result:Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
Chemical Information
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No. CAS 1616271-41-0
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Peso molecular 340.20
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Fòrmula C16H15Cl2NO3
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SMILES
O=C(C(Cl)Cl)NC1=CC(C2=CC=C(C(OC)=C2)OC)=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CCTA-1523 Related Classifications
HY-129301 Related Classifications
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