F15845
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment.
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- No. CAS: 470454-73-0
- Fòrmula: C20H25NO2S2
- Peso molecular:375.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
F 15845 (10 nM-10 μM) concentration-dependently reduces veratrine-induced diastolic contracture with an IC50 value of 0.14 μM in isolated atria[1].
F 15845 (0.1-10 μM) preserves viability in isolated cardiomyocytes exposed to lysophosphatidylcholine (LPC)[1].
F 15845 (0.3 μM) significantly counteracts [Na+] increase during no-flow ischemia[1].
F 15845 (0.3 μM, 0-35 min) delays the reduction in [Na+], but marks and maintains upon reperfusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[1]
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Dosage:2.5 mg/kg, 5 mg/kg
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Administration:intravenously
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Result:Significantly reduced infarct size, decreased of troponin I levels and limited the long-term expansion of infarct size.
Chemical Information
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No. CAS 470454-73-0
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Peso molecular 375.55
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Fòrmula C20H25NO2S2
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SMILES
COC(C=CC=C1)=C1SC[C@@H](C)CN[C@@H]2COC3=CC=CC=C3SC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
F15845 Related Classifications
HY-19463A Related Classifications
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