SRSF3 - serine and arginine rich splicing factor 3 Gene

Also Known as SFRS3; SRp20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6428

About SRSF3

Cytogenetic location: 6p21.31-p21.2 Genomic coordinates (GRCh38): 6:36,594,362-36,605,600 (from NCBI)

This gene has 8 transcripts (splice variants), 319 orthologues, 8 paralogues and is associated with 50 phenotypes. Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the Other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

SRSF3 Products (1)

mRNA	Protein	Name
NM_003017.5	NP_003008.1	serine/arginine-rich splicing factor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables RNA binding	IDA IDA: Inferred from direct assay	26876937	GOA
NOT enables pre-mRNA binding	IDA IDA: Inferred from direct assay	32440474	GOA
enables primary miRNA binding	IMP IMP: Inferred from mutant phenotype	33664453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14559993	GOA
enables protein-RNA sequence-specific adaptor activity	IDA IDA: Inferred from direct assay	32440474	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	28984244	GOA
involved in primary miRNA processing	IMP IMP: Inferred from mutant phenotype	33664453	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	26876937	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
is active in nuclear speck	IDA IDA: Inferred from direct assay	26876937	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF3 Protein Structure

RRM_1

0
100
164 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 3	epididymis secretory sperm binding protein

SRSF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SRSF3	P84103	PCDHB14	Homo sapiens	Q9Y5E9	Validated Y2H	32296183
Intra	SRSF3	P84103	SRSF8	Homo sapiens	Q9BRL6-2	Validated Y2H	32296183
Intra	SRSF3	P84103	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	SRSF3	P84103	RBM3	Homo sapiens	P98179	Validated Y2H	32296183
Intra	SRSF3	P84103	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	SRSF3	P84103	NXF1	Homo sapiens	Q9UBU9	Pull Down	17036044
Intra	SRSF3	P84103	CIRBP	Homo sapiens	Q14011	Validated Y2H	32296183
Intra	SRSF3	P84103	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SRSF3	P84103	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	SRSF3	P84103	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SRSF3	P84103	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	SRSF3	P84103	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	SRSF3	P84103	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
Intra	SRSF3	P84103	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	SRSF3	P84103	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	SRSF3	P84103	CLK2	Homo sapiens	P49760	Anti Tag CoIP	33961781
Intra	SRSF3	P84103	PCBP2	Homo sapiens	Q15366	Pull Down	17183366
Cross	SRSF3	P84103	Srek1	Rattus norvegicus	Q9JKL7	Anti Tag CoIP	14559993

Cross: Cross-species interaction Intra: Intraspecies interaction

SRSF3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82424	SRSF3 Antibody (YA2169)	WB, IHC-P, ICC/IF, FC	Mouse, Rat, Human

Related Diseases

Diseases	Alias
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Intellectual Developmental Disorder, Autosomal Dominant 4	MRD4 Autosomal Dominant Non-Syndromic Intellectual Disability 4 Mental Retardation, Autosomal Dominant 4 Autosomal Dominant Intellectual Developmental Disorder 4
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-148660	SFI003	Inducer	99.75%	Unkown
HY-125201	Indazole 1	Inhibitor	/	Unkown
HY-RS13794	SRSF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18844	Srsf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25336	Srsf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRSF3	VGNC	VGNC:77820
Rattus norvegicus	SRSF3	RGD	RGD:1309233
Canis familiaris	SRSF3	VGNC	VGNC:46819
Bos taurus	SRSF3	VGNC	VGNC:35301
Mus musculus	SRSF3	MGD	MGI:98285
Others	SRSF3	NCBI