Nomilin
Based on 3 publication(s) in Google Scholar
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.01%
- No. CAS: 1063-77-0
- Fòrmula: C28H34O9
- Peso molecular:514.56
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Nomilin
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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Cell Migration/Invasion Assay
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Apoptosis Analysis
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IF
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.097 μM
Compound: 11e
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Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay
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[PMID: 33289552] |
| MDA-MB-435 | IC50 |
0.78 μM
Compound: 11e
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Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay
Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay
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[PMID: 33289552] |
Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1063-77-0
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Appearance Solid
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Peso molecular 514.56
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Fòrmula C28H34O9
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Color White to off-white
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SMILES
C[C@]([C@@](CC1)([H])[C@]2([C@H](CC3=O)OC(C)=O)C)(C(C[C@@]2([H])C(C)(O3)C)=O)[C@@]4([C@@H]5O4)[C@@]1([C@H](C6=COC=C6)OC5=O)C
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Mol Med
Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer. [Abstract]2024 Sep 28;30(1):166. PMID: 39342122
Nomilin purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Sep 28;30(1):166. [Abstract]
MDA-MB-231 and BT-549 cells with or without Nomilin (10, 20, 50, 100, 150, 200, 250, 300, 400, 500 μM) treatment analysed by CCK-8 assay.
Nomilin purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Sep 28;30(1):166. [Abstract]
Western blot analysis of PCNA treated with Nomilin (150, 300 μM).
Nomilin purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Sep 28;30(1):166. [Abstract]
Wound healing assay was used to calculate migration rate treated with Nomilin (150, 300 μM).
Nomilin purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Sep 28;30(1):166. [Abstract]
Apoptosis of TNBC cells was analysed using flow cytometry treated with Nomilin (150, 300 μM).
Nomilin purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Sep 28;30(1):166. [Abstract]
Immunofluorescence analysis of Cleaved-Caspase3 treated with Nomilin (150, 300 μM).
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Vet Microbiol
Identification and evaluation of Nordihydroguaiaretic acid (NDGA) as an active traditional Chinese medicine compound inhibiting the 3C-like protease of feline infectious peritonitis virus. [Abstract]2025 Sep 15:310:110730. PMID: 40976146 -
Solvente y solubilidad
DMSO : 100 mg/mL (194.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Shi YS, et al. Nomilin protects against cerebral ischemia-reperfusion induced neurological deficits and blood-brain barrier disruption via the Nrf2 pathway. Food Funct. 2019 Sep 1;10(9):5323-5332. [Content Brief]
[2]. Sato R, et al. Nomilin as an anti-obesity and anti-hyperglycemic agent. Vitam Horm. 2013;91:425-39. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9434 mL | 9.7170 mL | 19.4341 mL | 48.5852 mL |
| 5 mM | 0.3887 mL | 1.9434 mL | 3.8868 mL | 9.7170 mL | |
| 10 mM | 0.1943 mL | 0.9717 mL | 1.9434 mL | 4.8585 mL | |
| 15 mM | 0.1296 mL | 0.6478 mL | 1.2956 mL | 3.2390 mL | |
| 20 mM | 0.0972 mL | 0.4859 mL | 0.9717 mL | 2.4293 mL | |
| 25 mM | 0.0777 mL | 0.3887 mL | 0.7774 mL | 1.9434 mL | |
| 30 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL | 1.6195 mL | |
| 40 mM | 0.0486 mL | 0.2429 mL | 0.4859 mL | 1.2146 mL | |
| 50 mM | 0.0389 mL | 0.1943 mL | 0.3887 mL | 0.9717 mL | |
| 60 mM | 0.0324 mL | 0.1620 mL | 0.3239 mL | 0.8098 mL | |
| 80 mM | 0.0243 mL | 0.1215 mL | 0.2429 mL | 0.6073 mL | |
| 100 mM | 0.0194 mL | 0.0972 mL | 0.1943 mL | 0.4859 mL |
Nomilin Related Classifications
HY-N0547 Related Classifications
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