1. Saccharides and Glycosides
  2. Escin IIa

Escin IIa 

Cat. No.: HY-107248
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Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats.

For research use only. We do not sell to patients.

Escin IIa Chemical Structure

Escin IIa Chemical Structure

CAS No. : 158732-55-9

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Description

Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

In Vivo

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1]
Dosage: 10-50 mg/kg
Administration: p.o.
Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats.
Molecular Weight

1101.23

Formula

C₅₄H₈₄O₂₃

CAS No.

158732-55-9

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Escin IIaOthersacuteinflammationgastriclesionsvascularethanol-inducedInhibitorinhibitorinhibit

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Escin IIa
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