F2276-0106
F2276-0106 is a biochemical reagent targeting the PCAF bromodomain (PDB 5FDZ). F2276-0106 is predicted to have good cell permeability and oral absorption, with physicochemical properties consistent with Lipinski's rule of five. F2276-0106 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 922054-57-7
- Formula: C19H20N2O5
- Molecular Weight:356.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
F2276-0106 exhibits a favorable docking score of -11.346 and forms key interactions with Asn803, Tyr809, and Tyr802 in the PCAF bromodomain[1].
F2276-0106 exhibits a highly favorable binding free energy with the PCAF bromodomain, at -84.379 kcal/mol[1].
F2276-0106 is predicted to possess favorable drug-like properties, including high human oral absorption and good cell permeability[1].
F2276-0106 has a small HOMO-LUMO energy gap, indicating that it is a chemically reactive molecule with electron transfer potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 922054-57-7
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Molecular Weight 356.38
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Formula C19H20N2O5
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SMILES
O=C1C2=CC(=CC=C2OCCN1C)NC(=O)COC3=CC=C(OC)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
F2276-0106 Related Classifications
HY-153144 Related Classifications
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