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Cat. No.: HY-147621

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FGFR-IN-6

FGFR-IN-6 (Compound 5) is a FGFR inhibitor. FGFR-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 2762955-18-8
Formula: C₂₃H₂₂N₆O₃
Molecular Weight:430.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

FGFR-IN-6 Chemical Structure

CAS No.: 2762955-18-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

FGFR-IN-6 (Compound 5) is a FGFR inhibitor^[1]. FGFR-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

FGFR-IN-6 (Compound 5) shows antiproliferation activity with IC₅₀ values of 0.5-5 nM against BaF3-Tel-FGFR2WT and various mutant FGFR2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2762955-18-8
Molecular Weight 430.46
Formula C₂₃H₂₂N₆O₃
SMILES

C=CC(N1CC[C@@H](C1)N2N=C(C(C(N)=O)=C2N)C#CC3=CC4=C(OC(C5CC5)=N4)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. DENG Haibing, et al. 1h-pyrazol-4-amide derivative, preparation method therefor, and use thereof. WO2022042613A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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