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Cat. No.: HY-121124

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Fluindione

Name: Fluindione
Brand: MedChemExpress
SKU: HY-121124
Price: 197.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Fluindione is a inhibitor of 5-lipoxygenase with the IC₅₀ of 15 μM. Fluindione has antiinflammatory activity.

For research use only. We do not sell to patients.

CAS No.: 957-56-2
Formula: C₁₅H₉FO₂
Molecular Weight:240.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fluindione Chemical Structure

CAS No.: 957-56-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Fluindione is a inhibitor of 5-lipoxygenase with the IC₅₀ of 15 μM. Fluindione has antiinflammatory activity^[1].

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-1	IC₅₀	9.6 μM Compound: 19	In vitro inhibition of 5-lipoxygenase activity in RBL-1 cells. In vitro inhibition of 5-lipoxygenase activity in RBL-1 cells.	10.1016/S0960-894X(00)80236-X

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 957-56-2
Molecular Weight 240.23
Formula C₁₅H₉FO₂
SMILES

O=C1C(C(C2=C1C=CC=C2)=O)C3=CC=C(C=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brooks, et al. Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase. Bioorganic & Medicinal Chemistry Letters, 2(10), 1309–1314.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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