Flupyradifurone
Based on 2 publication(s) in Google Scholar
Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 951659-40-8
- Formula: C12H11ClF2N2O2
- Molecular Weight:288.68
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Flupyradifurone
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Biological Activity
Flupyradifurone is a butenolide insecticide that activates insect nAChRs. Flupyradifurone is a butenolide insecticide and is considered friendly to honey bee fitness[1].
Flupyradifurone (FLF), an insecticide, compete with imidacloprid (IMI) for the same high affinity-binding site at the insect nAChR, the modulation of which leads to the toxic end point[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 951659-40-8
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Appearance Solid
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Molecular Weight 288.68
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Formula C12H11ClF2N2O2
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Color White to off-white
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SMILES
O=C1OCC(N(CC(F)F)CC2=CN=C(C=C2)Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (346.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (562 KB)
- English - EN (562 KB)
- Français - FR (562 KB)
- Deutsch - DE (562 KB)
- Norwegian - NO (562 KB)
- Español - ES (562 KB)
- Swedish - SV (562 KB)
- Italian - IT (562 KB)
- Korean - KR (562 KB)
- Portuguese - PT (562 KB)
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Handling Instructions (2659 KB)
References
[1]. Yi Guo, et al. The Effects of Exposure to Flupyradifurone on Survival, Development, and Foraging Activity of Honey Bees (Apis mellifera L.) under Field Conditions. Insects. 2021 Apr 16;12(4):357. [Content Brief]
[2]. Mark Montgomery, et al. Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators. J Med Chem. 2022 Jan 5. [Content Brief]
[3]. Yizhi Feng, et al. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS. Biomed Chromatogr. 2022 Jan 3;e5312. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4640 mL | 17.3202 mL | 34.6404 mL | 86.6011 mL |
| 5 mM | 0.6928 mL | 3.4640 mL | 6.9281 mL | 17.3202 mL | |
| 10 mM | 0.3464 mL | 1.7320 mL | 3.4640 mL | 8.6601 mL | |
| 15 mM | 0.2309 mL | 1.1547 mL | 2.3094 mL | 5.7734 mL | |
| 20 mM | 0.1732 mL | 0.8660 mL | 1.7320 mL | 4.3301 mL | |
| 25 mM | 0.1386 mL | 0.6928 mL | 1.3856 mL | 3.4640 mL | |
| 30 mM | 0.1155 mL | 0.5773 mL | 1.1547 mL | 2.8867 mL | |
| 40 mM | 0.0866 mL | 0.4330 mL | 0.8660 mL | 2.1650 mL | |
| 50 mM | 0.0693 mL | 0.3464 mL | 0.6928 mL | 1.7320 mL | |
| 60 mM | 0.0577 mL | 0.2887 mL | 0.5773 mL | 1.4434 mL | |
| 80 mM | 0.0433 mL | 0.2165 mL | 0.4330 mL | 1.0825 mL | |
| 100 mM | 0.0346 mL | 0.1732 mL | 0.3464 mL | 0.8660 mL |
Flupyradifurone Related Classifications
HY-145295 Related Classifications
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