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Cat. No.: HY-100590R

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FPH1 (Standard)

Name: FPH1 (Standard)
Brand: MedChemExpress
SKU: HY-100590R
Availability: PreOrder

(Synonyms: BRD6125 (Standard))

FPH1 (Standard) (BRD6125 (Standard)) is the analytical standard of FPH1 (HY-100590). This product is intended for research and analytical applications. FPH1 (BRD6125) is a hepatocyte proliferation agent that promotes functional proliferation of primary human hepatocytes and improves hepatocyte proliferation and secretory phenotypes. FPH1 promotes hepatocyte differentiation and maturation of human mesenchymal stem cells, and induces transcriptional upregulation of adult liver xenobiotic metabolism enzymes, including CYP2D6, CYP3A4, CYP2C19, and MAO-A. FPH1-induced chemical maturation confers primaquine sensitivity and reduces P. yoelii-luc and P. falciparum infection. FPH1 can be used in research related to liver diseases, such as liver failure and Plasmodium infection.

For research use only. We do not sell to patients.

CAS No.: 708219-39-0
Formula: C₁₆H₁₅ClF₂N₂O₃S
Molecular Weight:388.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPH1 (Standard) Chemical Structure

CAS No.: 708219-39-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-100590
FPH1

Hepatocyte Proliferation Agent

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Chemical Information
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 708219-39-0
Molecular Weight 388.82
Formula C₁₆H₁₅ClF₂N₂O₃S
SMILES

O=C(NC1=C(F)C=CC=C1F)CN(C2=CC(Cl)=CC=C2C)S(=O)(C)=O
Synonyms

BRD6125 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Ng S, et al. Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem cell reports. 2015 Mar 10;4(3):348-59.

[2]. Yuan L, et al. Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice. Theranostics. 2019;9(7):2115-2128.

[3]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology. 2013 Aug;9(8):514-20. [Content Brief]

[4]. Du C, et al. Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails. Stem cell research & therapy. 2018 Mar 09;9(1):58.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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