FITC-Dextran (MW 10000)
Based on 98 publication(s) in Google Scholar
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.
For research use only. We do not sell to patients.
- CAS No.: 60842-46-8
- Molecular Weight:10000.00(Average)
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Publications Citing Use of MedChemExpress (MCE) FITC-Dextran (MW 10000)
More- Signal Transduct Target Ther. 2025 Nov 14;10(1):368. [Abstract]
- Nat Metab. 2022 Sep;4(9):1138-1149. [Abstract]
- Nat Commun. 2024 Jan 19;15(1):613. [Abstract]
- ACS Nano. 2025 Dec 19. [Abstract]
- Gut Microbes. 2026 Dec 31;18(1):2657625. [Abstract]
- Gut Microbes. 2024 Jan-Dec;16(1):2377576. [Abstract]
- J Nanobiotechnology. 2025 Apr 15;23(1):291. [Abstract]
- Adv Sci (Weinh). 2025 Jul 18:e00741. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(30):e00461. [Abstract]
- Adv Sci (Weinh). 2025 Jan 9:e2412526. [Abstract]
- Adv Sci (Weinh). 2021 Oct;8(20):e2101912. [Abstract]
- Sci Adv. 2023 Oct 20;9(42):eadi0699. [Abstract]
- Biomaterials. 2022 Aug:287:121608. [Abstract]
- Brain. 2026 May 26:awag189. [Abstract]
- Pharmacol Res. 2024 May 21:205:107229. [Abstract]
- Cancer Lett. 2024 Jun 1:591:216897. [Abstract]
- Cell Commun Signal. 2025 Jun 4;23(1):263. [Abstract]
- Phytomedicine. 2023 Jul 25:116:154825. [Abstract]
- EBioMedicine. 2022 Aug:82:104181. [Abstract]
- Mater Today Bio. 2025 Oct 25:35:102466. [Abstract]
- Acta Pharmacol Sin. 2025 May;46(5):1345-1360. [Abstract]
- NPJ Sci Food. 2026 Mar 24. [Abstract]
- J Transl Med. 2024 Jun 5;22(1):535. [Abstract]
- Sci China Life Sci. 2025 Jul;68(7):2010-2027. [Abstract]
- Int J Biol Macromol. 2025 May 9:144084. [Abstract]
- Device. 2024 June 12
- Clin Transl Med. 2026 Apr;16(4):e70651. [Abstract]
- ACS Appl Mater Interfaces. 2026 Jun 17;18(23):32406-32418. [Abstract]
- Cell Rep. 2023 Jun 20;42(7):112660. [Abstract]
- Cell Rep. 2023 Apr 4;42(4):112346. [Abstract]
- Brain Behav Immun. 2026 May:134:106478. [Abstract]
- Brain Behav Immun. 2023 May:110:140-151. [Abstract]
- Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016(25)06272-8. [Abstract]
- Redox Rep. 2024 Dec;29(1):2433393. [Abstract]
- J Ethnopharmacol. 2025 Aug 18;353(Pt B):120435. [Abstract]
- J Ethnopharmacol. 2025 Apr 6:119744. [Abstract]
- J Ethnopharmacol. 2024 Nov 9;338(Pt 2):119068. [Abstract]
- J Ethnopharmacol. 2024 Oct 16;337(Pt 3):118937. [Abstract]
- J Ethnopharmacol. 2024 Mar 25:322:117567. [Abstract]
- J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117098. [Abstract]
- Ecotoxicol Environ Saf. 2024 Jul 23:282:116762. [Abstract]
- Food Front. 2026 May 28;7(4):e70301.
- Food Funct. 2021 Nov 29;12(23):11956-11965. [Abstract]
- Adv Mater Technol. 2026 Jun 17.
- Colloids Surf B Biointerfaces. 2026 Sep:265:115744. [Abstract]
- Int J Mol Sci. 2025 Oct 19;26(20):10161. [Abstract]
- Int Immunopharmacol. 2025 Jan 17:148:113972. [Abstract]
- Int Immunopharmacol. 2024 May 23:135:112263. [Abstract]
- Mol Neurobiol. 2025 Apr;62(4):4203-4220. [Abstract]
- Mucosal Immunol. 2024 Sep 6:S1933-0219(24)00093-X. [Abstract]
- mBio. 2026 Apr 8;17(4):e0389625. [Abstract]
- Front Pharmacol. 2024 Aug 29:15:1428572. [Abstract]
- Front Pharmacol. 2021 Nov 2:12:748568. [Abstract]
- Probiotics Antimicrob Proteins. 2025 Nov 26. [Abstract]
- Mol Med Rep. 2024 Jun;29(6):90. [Abstract]
- PLoS Pathog. 2025 Jan 2;21(1):e1012800. [Abstract]
- FEBS J. 2025 Nov 27. [Abstract]
- FEBS J. 2025 Mar;292(5):1052-1069. [Abstract]
- Curr Issues Mol Biol. 2022 Nov 29;44(12):5995-6005. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2026 May 16. [Abstract]
- J Funct Foods. 2024 Nov.
- J Tradit Complement Med. 2024 Apr 29;15(4):380-387. [Abstract]
- Neurotox Res. 2022 Aug;40(4):1020-1028. [Abstract]
- J Neurotrauma. 2025 Aug 29. [Abstract]
- Immun Inflamm Dis. 2024 Dec;12(12):e70107. [Abstract]
- Immun Inflamm Dis. 2022 Oct;10(10):e697. [Abstract]
- Biochem Biophys Rep. 2025 Nov 11:44:102351. [Abstract]
- BMC Infect Dis. 2025 Apr 20;25(1):565. [Abstract]
- Kaohsiung J Med Sci. 2024 Aug;40(8):710-721. [Abstract]
- J Steroid Biochem Mol Biol. 2023 Jul:231:106314. [Abstract]
- Immunobiology. 2023 Mar;228(2):152315. [Abstract]
- Cell Tissue Res. 2022 Sep;389(3):517-530. [Abstract]
- Vet Microbiol. 2026 Mar:314:110900. [Abstract]
- Int J Hyperthermia. 2025 Dec;42(1):2559022. [Abstract]
- Prev Nutr Food Sci. 2024 Dec 31;29(4):474-484. [Abstract]
- Biochem Biophys Res Commun. 2024 Sep 3:723:150176. [Abstract]
- Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282. [Abstract]
- Exp Ther Med. 2025 Nov 14;31(1):22. [Abstract]
- Exp Brain Res. 2021 Jan;239(1):341-350. [Abstract]
- Eur J Histochem. 2025 Jan 21;69(1). [Abstract]
- J Vis Exp. 2024 Dec 20:(214). [Abstract]
- medRxiv. 2026 Feb 19.
- Res Sq. 2026 Jan 19.
- Res Sq. 2025 Dec 15.
- iMetaOmics. 2025 Aug 06.
- bioRxiv. 2025 May 11.
- SSRN. 2025 May 21.
- SSRN. 2025 Mar 11.
- Res Sq. 2024 Aug 13.
- Biomed Pharmacother. 2024 Jun:175:116633. [Abstract]
- Research Square Preprint. 2024 Apr 9.
- Research Square Preprint. 2023 Oct 10.
- Research Square Preprint. 2023 Oct 23.
- Heliyon. 2023 Jul 16;9(7):e18325. [Abstract]
- SSRN. 2023 Jun 12.
- Research Square Print. 2023 Feb 23.
- Bioengineered. 2022 Mar;13(3):7209-7220. [Abstract]
- Bioengineered. 2022 Feb;13(2):3680-3693. [Abstract]
Customer Validation & Images
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
Biological Activity
Guide (The following is our recommended protocol. This protocol is only a guide and should be modified according to your specific needs).
1. Cell Marking (for cells undergoing apoptosis)[1]:
1.1 Resuspend cells in culture medium and add Propidium Iodide (PI) and FITC-Dextran to a final concentration of 7.5 μM and 1.13 μM, respectively.
1.2 Incubate cells at room temperature in the dark for 25 minutes.
1.3 Centrifuge at 500 g for 10 minutes and discard the supernatant.
1.4 Resuspend cells in culture medium and analyze using flow cytometry or fluorescence microscopy (PI: Ex=500 nm, Em=600 nm; FITC-Dextran: Ex=495 nm, Em=525 nm).
2. Side-cell permeability assay[4]
2.1 Add FITC-Dextran (0.1 mg/mL) to the basal medium in the upper chamber of the transwell.
2.2 Collect the medium from the lower chamber of the transwell after 15 minutes.
2.3 Measure the fluorescence signal (Ex=495 nm, Em=525 nm).
2.4 Calculate the FITC-Dextran concentration based on the fluorescence intensity.
2.5 Calculate the permeability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
For intestinal barrier function assay[5]
1. Fast mice for 4 h.
2. Orally gavage mice with FITC-Dextran MW 10000 (0.6 mg/g).
3. Measure fluorescence intensity of plasma in 4 h (excitation nm/emission 520 nm).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
525
488
Chemical Information
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CAS No. 60842-46-8
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Appearance Solid
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Molecular Weight 10000.00(Average)
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Color Yellow to brown
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SMILES
[FITC-Dextran (MW 10000)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (98)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors. [Abstract]2025 Nov 14;10(1):368. PMID: 41233352 -
Nat Metab
Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. [Abstract]2022 Sep;4(9):1138-1149. PMID: 36109623 -
Nat Commun
2024 Jan 19;15(1):613. PMID: 38242873 -
ACS Nano
Central Nervous System Targeting Nanovesicles for Trans-Barrier Delivery and Spinal Cord Injury Treatment. [Abstract]2025 Dec 19. PMID: 41420148 -
Gut Microbes
Dietary conjugated linoleic acid enhances resistance to Salmonella infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells. [Abstract]2026 Dec 31;18(1):2657625. PMID: 41964110 -
Gut Microbes
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation. [Abstract]2024 Jan-Dec;16(1):2377576. PMID: 39068517 -
J Nanobiotechnology
Exosome-shuttled miR-5121 from A2 astrocytes promotes BSCB repair after traumatic SCI by activating autophagy in vascular endothelial cells. [Abstract]2025 Apr 15;23(1):291. PMID: 40229869
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Apr 15;23(1):291. [Abstract]
FITC-dextran (1 mg/mL; 45 min) permeability assay was performed to assess the barrier function of bEnd.3 endothelial cells.
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Adv Sci (Weinh)
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress. [Abstract]2025 Jul 18:e00741. PMID: 40679368
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 18:e00741. [Abstract]
Intestinal permeability was assessed by FITC‐Dextran (0.6 mg/g; Oral gavage) assays on day 10 after DSS initiation (n = 6).
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Adv Sci (Weinh)
ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7. [Abstract]2025 Aug;12(30):e00461. PMID: 40650658 -
Adv Sci (Weinh)
Single-Cell Multi-omics Assessment of Spinal Cord Injury Blocking via Cerium-doped Upconversion Antioxidant Nanoenzymes. [Abstract]2025 Jan 9:e2412526. PMID: 39783786 -
Adv Sci (Weinh)
2021 Oct;8(20):e2101912. PMID: 34396716
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Oct;8(20):e2101912. [Abstract]
Large particle transport assays through µE‐BBB were conducted by passing of FITC‐dextran (100 µg/mL; 1 h) solution through the lumen compartment of the system and quantifying the amount of FITC‐dextran that had accumulated in the basolateral compartment.
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Oct;8(20):e2101912. [Abstract]
To evaluate the effect of erythrocytes on the permeability of the BBB, isolated erythrocytes from young or old mice, supplemented with FITC‐dextran (100 μg/mL; 1 h), were circulated through the µE‐BBB.
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Sci Adv
Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain. [Abstract]2023 Oct 20;9(42):eadi0699. PMID: 37851811
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 Oct 20;9(42):eadi0699. [Abstract]
Ex vivo imaging showed biodistribution of FITC-Dextran (MW 4000) (500 μg/mouse; i.v.; Single dose).
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Biomaterials
Targeted liposomes for combined delivery of artesunate and temozolomide to resistant glioblastoma. [Abstract]2022 Aug:287:121608. PMID: 35690021 -
Brain
NINJ1 hypomethylation enhances endothelial dysfunction in brain arteriovenous malformations. [Abstract]2026 May 26:awag189. PMID: 42189175 -
Pharmacol Res
Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke. [Abstract]2024 May 21:205:107229. PMID: 38782148 -
Cancer Lett
Spatiotemporal characteristics of tissue derived small extracellular vesicles is associated with tumor relapse and anti-PD-1 response. [Abstract]2024 Jun 1:591:216897. PMID: 38631664
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Jun 1:591:216897. [Abstract]
Fluorescence intensity of FITC-dextran (500 μg/mL; 36 h) in lower chamber of Transwell after incubation with TM-sEVs from patients with low relapse risk and high relapse risk in the upper chamber.
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Cell Commun Signal
2025 Jun 4;23(1):263. PMID: 40462136
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jun 4;23(1):263. [Abstract]
Quantitative analysis of FITC in serum collected from mice in the FITC-Dextran (MW 4000) (0.6 mg/g; Oral gavage; Single dose) intestinal permeability assay.
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Phytomedicine
Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway. [Abstract]2023 Jul 25:116:154825. PMID: 37178572 -
EBioMedicine
Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury. [Abstract]2022 Aug:82:104181. PMID: 35908416 -
Mater Today Bio
EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosis. [Abstract]2025 Oct 25:35:102466. PMID: 41215769 -
Acta Pharmacol Sin
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells. [Abstract]2025 May;46(5):1345-1360. PMID: 39643641 -
NPJ Sci Food
2026 Mar 24. PMID: 41876529 -
J Transl Med
S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation. [Abstract]2024 Jun 5;22(1):535. PMID: 38840216 -
Sci China Life Sci
Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease. [Abstract]2025 Jul;68(7):2010-2027. PMID: 40347213
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2025 Jul;68(7):2010-2027. [Abstract]
Blood FITC-Dextran (MW 4000) (200 mg/kg; Oral gavage; Single dose) levels. The results showed that METTL3-deficient mice presented significantly increased serum FITC levels, indicating increased mucosal permeability.
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Int J Biol Macromol
Alginate-gelatin hydrogel scaffolds for establishing physiological barriers on a gut-brain-axis microchip. [Abstract]2025 May 9:144084. PMID: 40350126
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 May 9:144084. [Abstract]
MFI variations with time in Ch1, Ch3 and Ch5 of 10 kDa FITC-dextran (0.1 mg/mL; 0-24 h) diffusion.
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Clin Transl Med
Mechanism of Gzma-mediated GEF-H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis. [Abstract]2026 Apr;16(4):e70651. PMID: 41943423 -
ACS Appl Mater Interfaces
Programmable Nanoarchitectonics for Artificial Cells via Coupled Multidimensional Regulation of Phase State and Multiscale Transport Dynamics. [Abstract]2026 Jun 17;18(23):32406-32418. PMID: 42258394 -
Cell Rep
Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish. [Abstract]2023 Jun 20;42(7):112660. PMID: 37342912 -
Cell Rep
Oral feeding of nanoplastics affects brain function of mice by inducing macrophage IL-1 signal in the intestine. [Abstract]2023 Apr 4;42(4):112346. PMID: 37022934 -
Brain Behav Immun
Targeting α7nAChR-driven brain endothelial pyroptosis mitigates HIV-1 gp120-induced blood-brain barrier breakdown. [Abstract]2026 May:134:106478. PMID: 41651130 -
Brain Behav Immun
Dietary fish oil improves autistic behaviors and gut homeostasis by altering the gut microbial composition in a mouse model of fragile X syndrome. [Abstract]2023 May:110:140-151. PMID: 36858183 -
Int J Radiat Oncol Biol Phys
Activation of Angiotensin Converting Enzyme 2 (ACE2) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS). [Abstract]2025 Sep 16:S0360-3016(25)06272-8. PMID: 40967372 -
Redox Rep
Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis. [Abstract]2024 Dec;29(1):2433393. PMID: 39620924
FITC-Dextran (MW 10000) purchased from MedChemExpress. Usage Cited in: Redox Rep. 2024 Dec;29(1):2433393. [Abstract]
Intestinal permeability measured by serum fluorescein isothiocyanate FITC-Dextran (MW 4000) (0.44 mg/g; Oral gavage; Single dose) levels.
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J Ethnopharmacol
Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy. [Abstract]2025 Aug 18;353(Pt B):120435. PMID: 40835194 -
J Ethnopharmacol
Glycine tabacina extract alleviates inflammatory bowel disease via NF-κB, JNK and Nrf2 signaling pathways. [Abstract]2025 Apr 6:119744. PMID: 40199409 -
J Ethnopharmacol
Magnolol preserves the integrity of the intestinal epithelial barrier and mitigates intestinal injury through activation of PPAR γ in COPD rat. [Abstract]2024 Nov 9;338(Pt 2):119068. PMID: 39522848 -
J Ethnopharmacol
Dachaihu decoction alleviates septic intestinal epithelial barrier disruption via PI3K/AKT pathway based on transcriptomics and network pharmacology. [Abstract]2024 Oct 16;337(Pt 3):118937. PMID: 39419306 -
J Ethnopharmacol
Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP/NLRP3 signaling pathway. [Abstract]2024 Mar 25:322:117567. PMID: 38122909 -
J Ethnopharmacol
Xihuang pill ameliorates colitis in mice by improving mucosal barrier injury and inhibiting inflammatory cell filtration through network regulation. [Abstract]2024 Jan 30;319(Pt 1):117098. PMID: 37640256 -
Ecotoxicol Environ Saf
Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice. [Abstract]2024 Jul 23:282:116762. PMID: 39047366 -
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Food Funct
Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway. [Abstract]2021 Nov 29;12(23):11956-11965. PMID: 34747428 -
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Colloids Surf B Biointerfaces
Design and mechanistic evaluation of charge-converting fusogenic liposomes for efficient nucleic acid delivery. [Abstract]2026 Sep:265:115744. PMID: 42068612 -
Int J Mol Sci
Berberine Alleviates Intestinal Inflammation by Disrupting Pathological Macrophage-Epithelial Crosstalk in Macrophage-Organoid Co-Culture Model. [Abstract]2025 Oct 19;26(20):10161. PMID: 41155453 -
Int Immunopharmacol
House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis. [Abstract]2025 Jan 17:148:113972. PMID: 39826453 -
Int Immunopharmacol
Geranylgeranylacetone mitigates sepsis-associated intestinal injury through CHIP-dependent anti-inflammation and anti-oxidative effect. [Abstract]2024 May 23:135:112263. PMID: 38788444 -
Mol Neurobiol
Embryonic 6:2 Fluorotelomer Alcohol Exposure Disrupts the Blood‒Brain Barrier by Causing Endothelial‒to‒Mesenchymal Transition in the Male Mice. [Abstract]2025 Apr;62(4):4203-4220. PMID: 39417922 -
Mucosal Immunol
2024 Sep 6:S1933-0219(24)00093-X. PMID: 39245144 -
mBio
ATP1A1 enhances porcine reproductive and respiratory syndrome virus type 2 attachment and internalization. [Abstract]2026 Apr 8;17(4):e0389625. PMID: 41773865 -
Front Pharmacol
Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis. [Abstract]2024 Aug 29:15:1428572. PMID: 39268469 -
Front Pharmacol
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection. [Abstract]2021 Nov 2:12:748568. PMID: 34795584 -
Probiotics Antimicrob Proteins
Potential Benefits of Metformin Via Roseburia Intestinalis in High-fat Diet-fed Mice With Colorectal Adenomas. [Abstract]2025 Nov 26. PMID: 41296177 -
Mol Med Rep
Octreotide attenuates intestinal barrier damage by maintaining basal autophagy in Caco2 cells. [Abstract]2024 Jun;29(6):90. PMID: 38577927 -
PLoS Pathog
2025 Jan 2;21(1):e1012800. PMID: 39746094 -
FEBS J
LC3-positive extracellular vesicles released from tumor cells promote lung metastasis of breast cancer by inducing vascular permeability. [Abstract]2025 Nov 27. PMID: 41307630 -
FEBS J
A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins. [Abstract]2025 Mar;292(5):1052-1069. PMID: 39279038 -
Curr Issues Mol Biol
2022 Nov 29;44(12):5995-6005. PMID: 36547069 -
Naunyn Schmiedebergs Arch Pharmacol
Asiaticoside alleviates inflammation and intestinal barrier dysfunction in Crohn's disease-like colitis in a manner associated with the RhoA/ROCK/MLC pathway. [Abstract]2026 May 16. PMID: 42142140 -
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J Tradit Complement Med
Tianqi pingchan granule promotes recovery of glymphatic system function in a rat model of l-DOPA-induced dyskinesia. [Abstract]2024 Apr 29;15(4):380-387. PMID: 40677540 -
Neurotox Res
Pramipexole Protects Against Traumatic Brain Injury-Induced Blood-Brain Barrier (BBB) Dysfunction. [Abstract]2022 Aug;40(4):1020-1028. PMID: 35524855 -
J Neurotrauma
Clostridium butyricum Restores Intestinal Barrier Integrity via the IL-22/Reg3 Pathway Following Traumatic Brain Injury in Mice. [Abstract]2025 Aug 29. PMID: 40879524 -
Immun Inflamm Dis
Neohesperidin Dihydrochalcone Alleviates Lipopolysaccharide-Induced Vascular Endothelium Dysfunction by Regulating Antioxidant Capacity. [Abstract]2024 Dec;12(12):e70107. PMID: 39699295 -
Immun Inflamm Dis
2022 Oct;10(10):e697. PMID: 36169256 -
Biochem Biophys Rep
HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagy. [Abstract]2025 Nov 11:44:102351. PMID: 41311371 -
BMC Infect Dis
Alleviating penicillin-resistant Streptococcus pneumoniae‑induced lung epithelial cell injury: mechanistic insights into effects of the optimized combination of main components from Yinhuapinggan granules. [Abstract]2025 Apr 20;25(1):565. PMID: 40254610 -
Kaohsiung J Med Sci
HMGB1 inhibition blocks ferroptosis and oxidative stress to ameliorate sepsis-induced acute lung injury by activating the Nrf2 pathway. [Abstract]2024 Aug;40(8):710-721. PMID: 38837857 -
J Steroid Biochem Mol Biol
A vitamin D deficient diet increases weight gain and compromises bone biomechanical properties without a reduction in BMD in adult female mice. [Abstract]2023 Jul:231:106314. PMID: 37088440 -
Immunobiology
Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10. [Abstract]2023 Mar;228(2):152315. PMID: 36608595 -
Cell Tissue Res
Endothelial cells induce degradation of ECM through enhanced secretion of MMP14 carried on extracellular vesicles in venous malformation. [Abstract]2022 Sep;389(3):517-530. PMID: 35786766 -
Vet Microbiol
Disruption of goat airway epithelial barrier function by caprine parainfluenza virus type 3 infection in an ALI model. [Abstract]2026 Mar:314:110900. PMID: 41576713 -
Int J Hyperthermia
Activation of the liver X receptor α protects the blood-brain barrier against heatstroke-induced injury. [Abstract]2025 Dec;42(1):2559022. PMID: 40954981 -
Prev Nutr Food Sci
Protective Effects of Peanut Sprouts from a Smart Farming System on the Barrier Function of Human Epithelial Cells. [Abstract]2024 Dec 31;29(4):474-484. PMID: 39759809 -
Biochem Biophys Res Commun
2024 Sep 3:723:150176. PMID: 38820627 -
Biochem Biophys Res Commun
2020 Dec 17;533(4):1276-1282. PMID: 33097186 -
Exp Ther Med
Atorvastatin ameliorates chronic subdural hematomas by interrupting the 'chronic subdural hematoma cycle' via inhibition of the inflammatory response. [Abstract]2025 Nov 14;31(1):22. PMID: 41367709 -
Exp Brain Res
Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis. [Abstract]2021 Jan;239(1):341-350. PMID: 33180154 -
Eur J Histochem
Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway. [Abstract]2025 Jan 21;69(1). PMID: 39836101 -
J Vis Exp
2024 Dec 20:(214). PMID: 39760378 -
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Biomed Pharmacother
YL-109 attenuates sepsis-associated multiple organ injury through inhibiting the ERK/AP-1 axis and pyroptosis by upregulating CHIP. [Abstract]2024 Jun:175:116633. PMID: 38670049 -
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Heliyon
miR-185-5p / ATG101 axis alleviated intestinal barrier damage in intestinal ischemia reperfusion through autophagy. [Abstract]2023 Jul 16;9(7):e18325. PMID: 37539299 -
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Bioengineered
The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction. [Abstract]2022 Mar;13(3):7209-7220. PMID: 35245993 -
Bioengineered
The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability. [Abstract]2022 Feb;13(2):3680-3693. PMID: 35081868
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[2]. Natarajan R, et al. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15. [Content Brief]
[3]. Eriksson I, et al. Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells. Methods Mol Biol. 2017;1594:179-189. [Content Brief]
[4]. Okabayashi K, et al. Cdc42 activates paracellular transport in polarised submandibular gland cells. Arch Oral Biol. 2021 Dec;132:105276. [Content Brief]
[5]. Yu W, et al. ACE2 contributes to the maintenance of mouse epithelial barrier function. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FITC-Dextran (MW 10000) Related Classifications
HY-128868 Related Classifications
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