gamma-DGG
Based on 1 Customer Validation
gamma-DGG is a competitive AMPA receptor blocker.
For research use only. We do not sell to patients.
- Purity: 99.16%
- CAS No.: 6729-55-1
- Formula: C7H12N2O5
- Molecular Weight:204.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
AMPA receptor[1]
gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left[1]. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6729-55-1
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Appearance Solid
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Molecular Weight 204.18
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Formula C7H12N2O5
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Color White to off-white
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SMILES
OC(CNC(CC[C@@H](N)C(O)=O)=O)=O
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Synonyms
γDGG; γ-D-Glutamylglycine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 100 mg/mL (489.76 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (122.44 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu XS, et al. The origin of quantal size variation: vesicular glutamate concentration plays a significant role. J Neurosci. 2007 Mar 14;27(11):3046-56. [Content Brief]
[2]. Crunelli V, et al. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus. J Physiol. 1983 Aug;341:627-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8976 mL | 24.4882 mL | 48.9764 mL | 122.4410 mL |
| 5 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | 24.4882 mL | |
| 10 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 15 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 20 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 25 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8976 mL | |
| 30 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 40 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 50 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL | |
| 60 mM | 0.0816 mL | 0.4081 mL | 0.8163 mL | 2.0407 mL | |
| 80 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 100 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2244 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
gamma-DGG Related Classifications
HY-100785 Related Classifications
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