AFM32a
Based on 2 publication(s) in Google Scholar
AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).
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- CAS No.: 2095109-82-1
- Formule: C25H29FN6O3
- Masse moléculaire:480.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Protein Arginine Deiminase 2 (PAD2)[1]
In the target engagement assay, the EC 50 of AFM32a (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of AFM32a overcomes its relatively poor ability to enter cells[1].
AFM32a (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095109-82-1
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Masse moléculaire 480.53
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Formule C25H29FN6O3
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SMILES
O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N
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Synonyms
PAD2-IN-1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury. [Abstract]2025 Aug 20:e11873. PMID: 40832885 -
Front Immunol
Interaction Between Macrophage Extracellular Traps and Colon Cancer Cells Promotes Colon Cancer Invasion and Correlates With Unfavorable Prognosis. [Abstract]2021 Dec 1:12:779325. PMID: 34925357
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AFM32a Related Classifications
HY-136557 Related Classifications
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