I-BOP
I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons.
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- CAS No.: 128719-90-4
- Formule: C23H29IO5
- Masse moléculaire:512.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
I-BOP (1-100 nM) activates the MAP kinase, stimulates the tyrosine phosphorylation, and thus causes the activation of PI3K signaling pathway[1].
I-BOP (0.1-3 μM) enhances the synaptic transmission in hippocampal CA1 neuron at low concentration by increasing the neurotransmitter release, inhibits the excitatory synaptic transmission in hippocampal CA1 neuron through reduction of membrane input resistance at high concentration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A7r5.HEL.TP cell
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Concentration:1-100 nM
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Incubation Time:24 h
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Result:Increased phosphorylated tyrosine.
Chemical Information
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CAS No. 128719-90-4
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Masse moléculaire 512.38
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Formule C23H29IO5
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SMILES
O=C(O)CCC/C=C\C[C@H]1[C@](O2)([H])CC[C@]2([H])[C@@H]1/C=C/[C@@H](O)COC3=CC=C(I)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Morinelli TA, et al., Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15;53(12):1823-32. [Content Brief]
[2]. Hsu KS, et al., Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. Br J Pharmacol. 1996 Aug;118(8):2220-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
I-BOP Related Classifications
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